CC-930
CC-930
CAS: 899805-25-5
Molecular Formula: C21H23F3N6O2
CC-930 - Names and Identifiers
CC-930 - Physico-chemical Properties
| Molecular Formula | C21H23F3N6O2 |
| Molar Mass | 448.44 |
| Density | 1.63±0.1 g/cm3(Predicted) |
| Boling Point | 626.4±65.0 °C(Predicted) |
| pKa | 15.05±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Human PMBC cells were able to inhibit the production of phosphorylation by phorbol-12-myristate-13-acetate (IC50=1 μm) by CC-930 after stimulation with c-Jun and phyto hemegutinin. CC-930 in 240 kinds of kinase, with significant selectivity. EGFR was the only non-MAP kinase that was inhibited by more than 50% at a concentration of 3 μm CC-930 (IC50=0.38 μm). At the concentration of 10 μm, the inhibitory effect of CC-930 on 75 receptors, ion channels and neurotransmitter transporters was not more than 50%. The inhibitory effect of CC-930 on CYP450 enzymes is not significant, and metabolism occurs under the action of CYP3A4 and 2D6. |
| In vivo study | In an acute PK-PD rat model of LPS-induced TNFα production, the in vivo TNFα production was reduced by 23% and 77% at 10 mg/kg and 30 mg/kg of CC-930, respectively, orally. CC-930 is well tolerated in vivo, and its effect is proportional to the dose. |
CC-930 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.23 ml | 11.15 ml | 22.3 ml |
| 5 mM | 0.446 ml | 2.23 ml | 4.46 ml |
| 10 mM | 0.223 ml | 1.115 ml | 2.23 ml |
| 5 mM | 0.045 ml | 0.223 ml | 0.446 ml |
Last Update：2024-01-02 23:10:35
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