Clofentezine
Clofentezine
CAS: 74115-24-5
Molecular Formula: C14H8Cl2N4
Clofentezine - Names and Identifiers
| Name | Clofentezine |
| Synonyms | APOLLO Apollo Panatac NC 21314 APOLLO(R) Acaristop CLOFENTEZIN CLOFETEZINE CLOFENTEZINE ACARISTOP(R) Clofentezine Apollo? Apollo SC Bis(2-chlorophenyl)-1,2,4,5-tetrazine 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine 3,6-BIS(2-CHLOROPHENYL)-1,2,4,5-TETRAZINE 1,2,4,5-Tetrazine, 3,6-bis(2-chlorophenyl)- |
| CAS | 74115-24-5 |
| EINECS | 277-728-2 |
| InChI | InChI=1/C14H8Cl2N4/c15-11-7-3-1-5-9(11)13-17-19-14(20-18-13)10-6-2-4-8-12(10)16/h1-8H |
Clofentezine - Physico-chemical Properties
| Molecular Formula | C14H8Cl2N4 |
| Molar Mass | 303.15 |
| Density | 1.3727 (rough estimate) |
| Melting Point | 182-185°C(lit.) |
| Boling Point | 457.37°C (rough estimate) |
| Flash Point | 290.4°C |
| Water Solubility | 2.522ug/L(temperature not stated) |
| Vapor Presure | 8.4E-10mmHg at 25°C |
| Appearance | neat |
| Merck | 13,2398 |
| BRN | 7137128 |
| pKa | -1.68±0.31(Predicted) |
| Storage Condition | 0-6°C |
| Refractive Index | 1.6300 (estimate) |
| Physical and Chemical Properties | Melting Point: 182.3 |
| Use | Is a high efficiency, low toxicity, broad-spectrum acaricide, used to control Apple and other fruit tree crown mites |
Clofentezine - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | XF6860000 |
| Toxicity | LD50 in rats, mice (mg/kg): >3200 orally; LC50 (96 hr) in rainbow trout: 100 mg/l (Bryan) |
Clofentezine - Upstream Downstream Industry
| Raw Materials | Acetic acid Hydrogen peroxide 2-Chlorobenzaldehyde Chlorine hydrazine hydrate Tetrahydrofuran Sodium nitrite Ethyl Alcohol |
Clofentezine - Introduction
This standard substance is mainly used for measuring instrument calibration, analytical method evaluation and quality control, as well as the content determination and residue detection of corresponding components in related fields such as food, hygiene, environment and agriculture. It can also be used for value traceability or as a standard liquid reserve solution. It is diluted step by step and configured into various standard solutions for work. Preparation of 1. Samples This standard substance is made of pure tetracarazine with accurate purity and fixed value as raw material, chromatographic acetone as solvent, and accurately configured by weight-volume method. Tetrazine, English name: Clofentezine,CAS number: 74115-24-5 2. traceability and setting method This standard substance takes the configuration value as the standard value, and uses high performance liquid chromatography-diode array detector (HPLC-DAD) to compare this batch of standard substances with quality control control samples to verify the preparation value. By using preparation methods, measurement methods and measuring instruments that meet the requirements of metrological characteristics, the traceability of the value of the standard substance is guaranteed. 3. characteristic measure value and uncertainty (see certificate) number name standard value (ug/mL) relative expansion uncertainty (%)(k = 2)BW10070 The uncertainty of the standard value of the 1003 of the four mite in acetone is mainly composed of raw material purity, weighing, constant volume and uniformity, stability and other uncertainty components. 4. uniformity test and stability inspection According to the JJF1343-2012 [General Principles and Statistical Principles of Standard Substance Setting], random sampling of sub-packed samples is carried out, uniformity test of solution concentration is carried out, and stability inspection is carried out. The results show that the standard material has good uniformity and stability. The standard substance is valid for 24 months from the date of setting the value. The development unit will continue to monitor the stability of the standard substance. If the value changes are found during the validity period, the user will be notified in time. 5. packaging, transportation and storage, use and precautions 1. Packaging: This standard substance is packed in borosilicate glass ampoules, about 1.2 mL/branch. When removing or diluting, the pipette quantity shall prevail. 2. Transportation and storage: ice bags should be transported, and extrusion and collision should be avoided during transportation; storage under freezing and dark conditions. 3. Use: Balance at room temperature (20±3 ℃) before unsealing, and shake well. Once the ampoule is opened, it should be used immediately and cannot be used as a standard substance after being fused again.
Last Update：2022-10-16 17:28:16
Clofentezine - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | Acute oral LD50> mg/kg in male and female rats, acute percutaneous LD50 in rats was 5000mg/kg, acute inhalation LC50 in rats was 9mg/L (4H). It has slight irritation to rabbit skin. Rats and dogs fed the test dose of 40mg/kg feed (2 years) and 50mg/kg feed (1 year). No carcinogenic, teratogenic, mutagenic effects. Wild duck acute oral LD50>3000mg/kg, quail> 7500mg/kg. Safe for fish. Rainbow trout LC50 100mg/L (96H), oral LD50>0.02mg/only bees. |
| biological activity | clofenteazine is a growth inhibitor, which has a strong lethal effect on mites. |
| Use | tetrazine acaricide, an inhibitor of embryonic development, which mainly kills the eggs, but also has a certain effect on the young mites, no effect on adult mites. The effect is slow, the sustained effect period is 50 ~ 60d, and the highest acaricidal effect can be achieved 2~3 weeks after administration. For fruit trees, peas, citrus, ornamental plants, cotton and other crops, the control of whole claw mites and spider mites, the whole claw mites (Apple Red Spider) of the winter eggs is particularly effective. Safe for predatory mites and beneficial insects. In general, 1 times before and after flowering, each time according to the concentration of 100 ~ 125mg/L spray. It is a high-efficiency, low-toxicity and broad-spectrum acaricide, which is used to control mites on the crown of Apple and other fruit trees |
| production method | (2-ClC6H4CClN)2 is prepared by the interaction of O-chlorobenzaldehyde with sodium nitrite and chlorine, alternatively, (2-ClC6H4CClN)2 is prepared by reacting 2-chlorobenzoyl chloride with N2H4 (diluted with ethanol) and then with pcl5. Finally, it is reacted with hydrazine hydrate in the presence of a phase transfer catalyst to produce tetra-acarazine. |
Last Update：2024-04-10 22:29:15
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Raw Materials for Clofentezine