Cresol
Cresol
CAS: 1319-77-3
Molecular Formula: C7H8O
Cresol - Names and Identifiers
| Name | Cresol |
| Synonyms | Cresol cresoli Cresols bacillol CRESOL,CP artoluenol Methylphenol Crude phenols MIXED CRESOLS Cresylic acid coaltarphenols 2-methylphenol Crude carbolic acid METHYLPHENOL TRICRESOL Cresols (all isomers). Cresol (mixed isomers) m-cresol,o-cresol,p-cresol Cresol(mixture of isomers) Cresol, mixture of isomers Gemisch aus o-, m- und p-Kresol CresolMixedIsomers(CresylicAcid) CRESOL MIXTURE OF ISOMERS, CRUDE |
| CAS | 1319-77-3 |
| EINECS | 215-293-2 |
| InChI | InChI=1/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3 |
| InChIKey | QTWJRLJHJPIABL-UHFFFAOYSA-N |
Cresol - Physico-chemical Properties
| Molecular Formula | C7H8O |
| Molar Mass | 108.14 |
| Density | 1.04 |
| Melting Point | -1--2°C |
| Boling Point | 88-94°C |
| Flash Point | 82°C |
| Water Solubility | 1.932 g/100 mL |
| Vapor Presure | 0.379mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Almost colorless |
| Odor | Sweet, tarry. |
| Exposure Limit | TLV-TWA (skin) for all isomers, 5 ppm(～22 mg/m3 ) (ACGIH, MSHA, and OSHA),10-hour TWA 2.3 ppm (～10 mg/m3 )(NIOSH), IDLH 250 ppm (NIOSH). |
| Merck | 14,2579 |
| Storage Condition | Store at R.T. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5410 to 1.5440 |
| Physical and Chemical Properties | Density 1.04 melting point -1-2°C boiling point 88-94°C flash point 82°C water solubility 1.932g/100 mL |
| Use | Used as a raw material for synthetic resins, insulating paints, antioxidants, also used as disinfectants and solvents |
Cresol - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R20 - Harmful by inhalation R24/25 - R34 - Causes burns R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R68 - Possible risk of irreversible effects |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 2076 6.1/PG 2 |
| WGK Germany | 1 |
| RTECS | GO5950000 |
| FLUKA BRAND F CODES | 8-23 |
| HS Code | 29071219 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
Cresol - Upstream Downstream Industry
| Raw Materials | Cresol Sulfuric acid Sodium hydroxide |
| Downstream Products | m-Anisidine |
Cresol - Nature
Open Data Verified Data
A mixture of ortho-, meta-and para-cresol isomers. Colorless, pale yellow or pink liquid. There is phenol odor. Flammable. Soluble in ethanol, ethylene glycol and dilute alkali. The relative density ranged from 1. 030 to 1. 047. Melting Point 11~35 °c. Boiling point 191~203 deg C.
Last Update：2025-06-10 22:55:16
Cresol - Preparation Method
Open Data Verified Data
- toluene sulfonation method toluene is sulfonated with sulfuric acid to produce toluenesulfonic acid, which is then neutralized with sodium sulfite and subjected to alkali fusion and acidification to obtain a mixed cresol and a by-product portion of phenol.
- the coal tar fractionation method is obtained by fractionation of crude phenol, which is a by-product of high temperature coking.
Last Update：2022-01-01 10:41:44
Cresol - Standard
Authoritative Data Verified Data
This product is a mixture of various cresol isomers obtained by fractionation in coal tar.
Last Update：2024-01-02 23:10:35
Cresol - Trait
Authoritative Data Verified Data
- This product is almost colorless, light purple red or light brown yellow clear liquid; There is similar to the smell of phenol, and micro-strip coke odor; Long storage or in the sun, color gradient deep; saturated aqueous solutions show neutral or weakly acidic reactions.
- This product can be mixed with ethanol, chloroform, ether, glycerol, fatty oil or volatile oil at will, and slightly dissolved in water to generate a turbid solution; Dissolved in sodium hydroxide solution.
relative density
The relative density of this product (General 0601) is 1.030~1.050. Distillation range take this product, according to the determination method of distillation range (General 0611), the amount of 190~205 C distillation should be not less than 85%(ml/ml).
Last Update：2022-01-01 11:38:18
Cresol - Application
Open Data Verified Data
used in phenolic resin, electrical insulation paint, tricresyl phosphate, dyes, disinfectants, surfactants, flotation agents, lubricating oil additives, enamel solvents. Used as a preservative, cold plastic plasticizer, cracking dispersant and solvent in the production process of Sebacic acid.
Last Update：2025-08-19 16:24:40
Cresol - Differential diagnosis
Authoritative Data Verified Data
- take the saturated aqueous solution of this product and add ferric chloride solution, which is the purple blue color that is easy to disappear.
- take the saturated aqueous solution of this product and add bromine test solution to precipitate light yellow flocculent precipitate.
Last Update：2022-01-01 11:38:18
Cresol - Safety
Open Data Verified Data
- toxic, absorbed can not only cause central nerve paralysis, but also can be released in the kidney, causing nephritis and death. The maximum allowable concentration in the air of the workplace is 5 x 10-6.
- galvanized iron drum, 200kg per barrel. Store in a cool and ventilated place. The hazardous materials shall be stored and transported according to the regulations.
Last Update：2025-06-10 22:55:16
Cresol - Exam
Authoritative Data Verified Data
hydrocarbons
take 1.0ml of this product, Add 60ml of water to dissolve it, if it is turbid, take 57ml of water, add L. 5ml of sulfuric acid titration solution (0.01mol/L) and 2ml of barium chloride test solution, shake, place for 5 minutes] comparison, not more concentrated.
Non-volatile
take this product, put it on a water bath, and dry it at 105°C to constant weight. The residue should not exceed 0.1%.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 0.8%.
Last Update：2022-01-01 11:38:19
Cresol - Category
Authoritative Data Verified Data
Disinfection antiseptic.
Last Update：2022-01-01 11:38:19
Cresol - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:38:19
Cresol - Saponated Cresol Solution
Authoritative Data Verified Data
This product contains Cresol (C7H80) should be labeled the amount of 85.0% ~ 110.0%.
prescription
cresol 520g(500ml)
Vegetable oil 173g
Appropriate amount of sodium hydroxide (about 27g)
Appropriate amount of water
Made up to 1000ml
preparation method
take sodium hydroxide, add 100ml of water to dissolve, let it cool, add human vegetable oil with constant stirring, emulsify evenly, place it for 30 minutes, and slowly heat it (indirect steam or water bath), when the color of the soap body is deepened, it is transparent and then stirred; And can be proportionally prepared into small samples, check the unsaponifiable matter, if qualified, it is considered that the Saponification is complete; while hot, add cresol and stir until the soap block is completely dissolved, let it cool, and then add appropriate amount of water to make the total amount to 1000ml. The vegetable oil in the prescription can be replaced by low and medium carbon fatty acids.
trait
- This product is a yellow-brown to red-brown viscous liquid with the odor of cresol.
- This product can be mixed with ethanol to form a clear liquid.
examination
- alkalinity: take 1.0 of this product and dilute it with 20ml of neutral ethanol (neutral to phenolphthalein indicator solution), then add 1ml of phenolphthalein indicator solution, such as red, with sulfuric acid titration solution (0.05mol/L) titration, consumption of sulfuric acid titration solution (0.05mol/L) should not pass 1.0.
- unsaponifiable matter take 5ml of this product, add water 95ml, mix well, the solution should be clear; If it is turbid, with the control solution (take 6ml of standard potassium sulfate solution, add water 80ml and dilute hydrochloric acid 1ml, after the color tone is similar to that of the test solution, add 3ml of 25% barium chloride solution, add water to ML, shake well, and place for 10 minutes), not more concentrated.
- loading capacity take this product, according to the minimum loading capacity inspection method (General 0942) inspection, should comply with the provisions.
- microbial limit take this product as non-sterile product microbial limit test: microbial count method (General 1105) and control bacteria test method (General 1106) and non sterile drugs microbial limit standard (General 1107) inspection, should meet the requirements.
Content determination
- was measured by gas chromatography (General 0521).
- chromatographic conditions and system suitability test 50% cyanopropyl phenyl dimethyl polysiloxane was used as the stationary liquid, and the column temperature was 110°C. The number of theoretical plates shall not be less than 5000 based on the calculation of O-cresol peak, and the separation degree between the peak of internal standard substance and O-cresol peak, P-cresol peak and m-cresol peak shall meet the requirements. Preparation of internal standard solution an appropriate amount of benzaldehyde was taken and anhydrous ethanol was added to prepare a solution containing 1.5mg per 1 ml, which was obtained.
- determination of Precision Sample 2ml of this product, set it in a separatory funnel, add 0.1ml of hydrochloric acid, shake well, add 3ml of water, shake well, Precision Add 20ml of ether, gently shake and extract, the mixture was allowed to stand in layers, and the water layer was discarded. Precisely take 5ml of the ether extract, put it in a 25ml measuring flask, dilute it to the scale with absolute ethanol, and shake it well. Take 1 ml, put it in a 10ml measuring flask, add 2ml of internal standard solution, dilute to the scale with absolute ethanol, shake well, and use it as a test solution. In addition, about 25mg of O-cresol reference substance, about 25mg of p-formic acid reference substance and about 40mg of M-trypan reference substance were accurately weighed into a 10ml measuring flask, and 2ml of internal standard solution was added, absolute ethanol was added to dissolve and dilute to the scale, and the solution was shaken as a control solution. 1ul of each of the reference solution and the test solution were injected into the gas chromatograph respectively, and the contents of O-cresol, P-cresol and m-cresol were calculated by the peak area according to the internal standard method, and the sum was calculated.
category
with cresol.
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:38:20
Cresol - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | cresol can be used in the synthesis of materials auxiliaries and dye intermediates. used as raw material of synthetic resin, insulating paint, antioxidant, also used as disinfectant and solvent used in phenolic resin, electrical insulating paint, tricresyl phosphate, dye, surfactant, flotation agent, lubricant additive, enamel solvents, preservatives, cold-proof plastic plasticizers, cracking dispersants and sebacic acid in the production process of solvents. The bactericidal power of cresol is 4 times that of phenol, and soap water is usually added to the mixed cresol to emulsify, that is, to form the disinfectant LyX water. The separation of O-, m-and p-cresol from mixed cresol, including the mixture of m-cresol, has a wide range of applications in organic synthesis. solvent, Disinfection preservative, bactericidal for 4 times of carbolic acid. Synthetic resin. |
| identification | 1. Take the saturated aqueous solution of this product and add ferric chloride solution, which is the purple blue color that is easy to disappear. 2. Take the saturated solution of this product and add bromine test solution to precipitate light yellow flocculent precipitate. |
| production method | There are many methods for synthesizing cresol, and the content of isomers in the products obtained by each method is also different. The process of toluene sulfonation is similar to that of benzene sulfonation to phenol. Toluene was first sulfonated to give toluene sulfonic acid, and the molten sulfonated product was then treated with sodium hydroxide to give the sodium salt of cresol. The sodium salt is mixed with water and acidified by the addition of sulfur dioxide or by the addition of sulfuric acid to give cresol. After the moisture of the crude cresol was distilled off under a low degree of vacuum, a fraction of 150-200 ° C. Was collected under a vacuum of (80-93.3kPa) to obtain mixed cresol. Among them, the ratio of the Ortho, Inter and the three isomers varies with the reaction conditions. In general, the para position is the most, the meta position is less, and the ortho position is less. This method consumes 30% of toluene and 5000 of liquid alkali per ton of mixed cresol. 2. Methyl isopropyl benzene oxidation method this is the United States of the United States hergris explosives company to use the method. Toluene was alkylated with propylene to give a mixture of methyl isopropylbenzene with a ratio of 2.5 to 3:1 of Inter, para and steric isomers, in which the ortho isomer was small. Methyl cumene is then oxidized to methyl cumene peroxide at 25-35 °c by introduction of an oxygen-containing gas, which is then treated with sulfuric acid to obtain cresol rich in meta-isomer and para-isomer, and acetone is co-produced. This method is similar to the process of producing phenol and acetone by cumene method. The method of coal tar fractionation is obtained by fractionation of crude phenol, which is a by-product of high temperature coking. |
| category | corrosive article |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 1454 mg/kg; Oral-mouse LD50: 760 mg/kg |
| explosive hazard characteristics | explosive when mixed with air; Corrosive skin, cornea |
| flammability hazard characteristics | flammable; Hot gas |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant. |
| fire extinguishing agent | dry powder, carbon dioxide, foam, water mist |
| Occupational Standard | TLV-TWA 5 PPM (22 mg/m3) |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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Raw Materials for Cresol
Downstream Products for Cresol