Cysteamine
cysteamine
CAS: 60-23-1
Molecular Formula: C2H7NS
Cysteamine - Names and Identifiers
Cysteamine - Physico-chemical Properties
| Molecular Formula | C2H7NS |
| Molar Mass | 77.15 |
| Density | 0.934 (estimate) |
| Melting Point | 95°C |
| Boling Point | 130 °C |
| Water Solubility | Soluble in water |
| Solubility | Soluble in water (Miscible), methanol, ether (Very slightly), alcohol, and alkaline media |
| Appearance | White crystal |
| Color | White to slightly yellow |
| Merck | 14,2779 |
| BRN | 635649 |
| pKa | 8.35(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable, but may be air-sensitive. Incompatible with strong oxidizing agents. |
| Sensitive | Easy to absorb moisture and `sensitive` to carbon dioxide |
| Refractive Index | 1.5300 (estimate) |
| MDL | MFCD00008196 |
| Physical and Chemical Properties | White crystals. Melting point 99-100 °c. Soluble in water and alcohol, alkaline reaction, easy oxidation into disulfide in the air. The free base is extremely unstable and is generally made into hydrochloride [156-57-0]. |
| Use | Used as a Biochemical reagent |
Cysteamine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 3259 |
| WGK Germany | 3 |
| RTECS | KJ0175000 |
| FLUKA BRAND F CODES | 1-3-10-13-34 |
| HS Code | 29309090 |
| Toxicity | LD50 in mice (mg/kg): 625 orally; 250 i.p. (Klayman); (Srivastava, Field) |
Cysteamine - Reference
| Reference Show more | 1. Zhao Dan, Wei Chunjin, Zeng Mei, Wang Fen. Determination of N-acetyl-L-cysteine by fluorescence quenching-recovery method based on CdTe quantum dots [J]. Journal of South-Central University for Nationalities (Natural Science Edition),2017,36(04):17-21. 2. Xiaowei Mu, Minxing Wu, Bo Zhang, Xin Liu, Shaomei Xu, Yibing Huang, Xinghua Wang, Daqian Song, Pinyi Ma, Ying Sun,A sensitive "off-on" carbon dots-Ag nanoarticles spiral probe for cysteine detection via the inner filter effect,Talanta,Volume 22 3. [IF = 9.594] Fang Gao et al."Rational design of high quality citric acid-derived carbon dots by selecting efficient chemical structure motifs."Carbon. 2017 Feb;112:131 4. [IF=4.546] Mina Nan et al."Rapid Determination of Ochratoxin A in Grape and Its Commodities Based on a Label-Free Impedimetric Aptasensor Constructed by Layer-by-Layer Self-Assembly."Toxins. 2019 Feb;11(2):71 5. [IF=6.057] Xiaowei Mu et al."A sensitive “off-on” carbon dots-Ag nanoparticles fluorescent probe for cysteamine detection via the inner filter effect."Talanta. 2021 Jan;221:121463 6. [IF=4.015] Hao Yu et al."Effects of low-molecular-weight organic acids/thiols on hydroxyl radical production from natural siderite oxidation."Chem Geol. 2021 Dec;584:120537 7. [IF=3.807] Mengke Yu et al."Gold nanostructure-programmed flexible electrochemical biosensor for detection of glucose and lactate in sweat."J Electroanal Chem. 2021 Feb;882:115029 |
Cysteamine - Introduction
Easily soluble in water and alcohol, alkaline reaction, easy to oxidize into disulfide in the air. Free alkali is extremely unstable and is generally made into hydrochloride [156-57-0].
Last Update：2022-10-16 17:26:55
Cysteamine - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | 2-aminooethanethol (cysteamine, β-mercaptoethylamine, 2-Mercaptoethylamine, thioetholamine, Mercaptamine) is a radioprotective agent, cystamine can be formed by oxidation in air. |
| Usage | is a strong dopamine-β-hydroxylase inhibitor, leading to dopamine accumulation, dopamine strongly promotes the synthesis and secretion of GH in the hypothalamus. The active ingredients can improve the body's nutrient absorption and transformation, improve the growth rate of livestock and poultry, reduce body fat deposition, inhibit protein degradation, promote protein synthesis and other physiological regulation. used as a Biochemical reagent It has the effect of relieving the damage of metals to the enzyme system in the body and has antioxidant properties, which can prevent the damage of X-rays and radioactive substances. Pharmaceutical, pesticide, cosmetic intermediates. |
| production method | β-bromoethylamine is obtained by the addition of ethanolamine and hydrogen bromide, which is then cyclized with carbon disulfide in the presence of sulfuric acid, finally, it was obtained by hydrolysis. This method is easy to control the reaction, the equipment requirements are not high, suitable for industrial use. In addition, it can also be obtained by the addition of cycloethylamine and hydrogen sulfide. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | intraperitoneal-rat LD50: 232 mg/kg; Oral-mouse LD50: 625 mg/kg |
| flammability hazard characteristics | flammability; Toxic nitrogen oxide and sulfur oxide fumes from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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Mobile: +86-18621343501
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