D-methionine
D-Methionine
CAS: 348-67-4
Molecular Formula: C5H11NO2S
D-methionine - Names and Identifiers
| Name | D-Methionine |
| Synonyms | H-D-Met-OH D-LOBAMINE H-D-MET-OH D-Methionine D-METHIONINE D-BANTHIONINE d-2-amino-4-(methylthio)butyric acid D-2-AMINO-4-[METHYLTHIO]BUTANOIC ACID (R)-2-AMINO-4-(METHYLMERCAPTO)BUTYRIC ACID (r)-2-amino-4-(methylmercapto)butyric acid (2R)-2-Amino-4-methylsulfanylbutanoic acid |
| CAS | 348-67-4 |
| EINECS | 206-483-6 |
| InChI | InChI=1/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1 |
D-methionine - Physico-chemical Properties
| Molecular Formula | C5H11NO2S |
| Molar Mass | 149.21 |
| Density | 1.113 (estimate) |
| Melting Point | 273-275 °C |
| Boling Point | 306.9±37.0 °C(Predicted) |
| Specific Rotation(α) | -24 º (c=8, 6N HCl) |
| Flash Point | 139.4°C |
| Water Solubility | 53 g/L (20 ºC) |
| Solubility | 53 g/L (20°C) |
| Vapor Presure | 0.00017mmHg at 25°C |
| Appearance | White crystal or crystal |
| Color | White to off-white |
| Merck | 14,5975 |
| BRN | 1722293 |
| pKa | 2.23±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5216 (estimate) |
| MDL | MFCD00002622 |
| Physical and Chemical Properties | Melting point 273-275°C specific optical rotation -24 ° (c = 8, 6N HCl) water-soluble 53g/L (20°C) |
| Use | For biochemical research and nutritional supplements, used as biochemical reagents |
| In vitro study | The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. In plasma, an early CP hydrolysis product reacts with Methionine to form a 1:1 complex that is followed by the formation of a 2:1 compound at a later time point. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities. |
| In vivo study | When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01) while not significantly different from controls or from animals treated only with D-methionine (P>0.05). When Methionine is administered alone the average cell density is 0.95±0.099 (SEM) and not significantly different from controls (P>0.05). |
D-methionine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R33 - Danger of cumulative effects R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | PD0455000 |
| TSCA | Yes |
| HS Code | 29304090 |
D-methionine - Reference
| Reference Show more | 1. [IF=3.935] Min Zhang et al."Chemical profile and miscarriage prevention evaluation of Jiao-ai decoction, a classical traditional Chinese formula."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114832 |
D-methionine - Introduction
Soluble in water, solubility in water: 53G/L (20°C), dilute acid and alkali, very slightly soluble in alcohol, insoluble in ether.
Last Update：2022-10-16 17:24:47
D-methionine - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Methionine (MRX-1024; D-Methionine) is an effective chemical protective agent, which can also inhibit neuronal activity by activating GABAA receptors. |
| target | GABA A receptor |
| Use | Used as a biochemical reagent. Used for biochemical research and nutritional supplements |
Last Update：2024-04-09 20:52:54
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