Dasatinib
Dasatinib
CAS: 302962-49-8
Molecular Formula: C22H26ClN7O2S
Dasatinib - Names and Identifiers
| Name | Dasatinib |
| Synonyms | SPRYCEL CS-1968 SPRYCEL Dasatinib BMS354825 BMS-354825 NCGC00181129 intermediate sprycel Dasatinib DASATINIB (BMS 354825) Dasatinib (Dasatinib Monohydrate) Tablet N-(2-chloro-6-Methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-Methyl-4-pyriMidinyl]aMino]-1,3-thiazole-5-carboxaMide |
| CAS | 302962-49-8 |
| EINECS | 801-607-0 |
| InChI | InChI=1/C22H26ClN7O2S.H2O/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31;/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27);1H2 |
Dasatinib - Physico-chemical Properties
| Molecular Formula | C22H26ClN7O2S |
| Molar Mass | 488.01 |
| Density | 1.408±0.06 g/cm3(Predicted) |
| Melting Point | 275-286°C |
| Solubility | Soluble in DMSO (up to 200 mg/ml). |
| Appearance | White powder. |
| Color | White or off-white |
| pKa | 10.94±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| Physical and Chemical Properties | White solid |
| Use | Directly targets wild-type and mutant c-Abl kinase domains |
Dasatinib - Risk and Safety
| HS Code | 29341000 |
Dasatinib - Introduction
Dasatinib is a Src/Abl inhibitor, which has inhibitory effects on both raw Abl and Src kinase. IC50 is 0.6 nM and 0.8 nM respectively.
Last Update：2022-10-16 17:24:25
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