Dazoxiben
Dazoxiben
CAS: 78218-09-4
Molecular Formula: C₁₂H₁₃ClN₂O₃
Dazoxiben - Names and Identifiers
Dazoxiben - Physico-chemical Properties
| Molecular Formula | C₁₂H₁₃ClN₂O₃ |
| Molar Mass | 268.70 |
| Melting Point | 230-235°C |
| Solubility | DMSO : 62.5 mg/mL (232.60 mM; Need ultrasonic) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Chemical Properties Dazoxy Benzene Hydrochloride (Dazoxiben Hydrochloride):C12H12N2O3?HCl. [74226-22-5]. White crystals are obtained from ethanol and ether. Melting point 230~235 ℃, melting point 239~241 ℃. |
| Use | Uses selective inhibitors of TVA2 (thrombus A2) synthetase, selective inhibitors of thromboxane A2 synthetase. Used in the treatment of angina pectoris, and tried in the treatment of thromboembolic diseases, such as myocardial infarction and Raynaud's disease. |
| Target | Thromboxane (TX) synthase |
Dazoxiben - Upstream Downstream Industry
| Raw Materials | Acetic acid Potassium carbonate p-Toluenesulfonic acid 1,2-Dichloroethane Ethylparaben ETHYL 4-(2-CHLOROETHOXY)BENZOATE |
Dazoxiben - Reference
| Reference Show more | 1. Patrignani P , Filabozzi P , Catella F , et al. Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism.[J]. journal of pharmacology & experimental therapeutics, 1984, 228(2):472-477.2. Yu S M , Wu T S , Teng C M . Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor[J]. British Journal of Pharmacology, 1994, 111(3). |
Dazoxiben - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.722 ml | 18.608 ml | 37.216 ml |
| 5 mM | 0.744 ml | 3.722 ml | 7.443 ml |
| 10 mM | 0.372 ml | 1.861 ml | 3.722 ml |
| 5 mM | 0.074 ml | 0.372 ml | 0.744 ml |
Last Update：2024-01-02 23:10:35
Dazoxiben - Production method
Method 1: Ethyl p-hydroxybenzoate, 50% sodium hydroxide, 1, 2-dichloroethane and TBOE, stirred at 60°C. Cold to room temperature, acidified with 2mol/L hydrochloric acid to a Ph value of about 2. The organic layer is divided, and the water layer is extracted with dichloroethane. Organic layers are combined, washed and dried. Concentrate, wash with ether, and dry to obtain compound (I) in 86% yield. Imidazole and 40% sodium hydroxide were stirred together until completely dissolved, dimethylformamide, compound (I) and TBOE were added, and stirred at 40 ℃. Steam out the solvent under reduced pressure and cool to room temperature. Add water to dissolve and acidify, and chloroform is extracted 3 times. The extracts are combined, washed with water and dried. Concentrated and recrystallized with glacial acetic acid to obtain dazoxybenzene hydrochloride with 78% yield and melting point 238-241 ℃.
Method 2: Ethyl p-hydroxybenzoate, p-toluenesulfonic acid (2-chloroethyl) ester, anhydrous potassium carbonate and butanone were stirred and refluxed. Concentrate and pour the residual liquid into the water while it is hot. The solid was filtered, washed with water until neutral, and recrystallized with ethanol to obtain ethyl 4-(2-chloroethoxy) benzoate with 85.7% yield.
4-(2-chloroethoxy) ethyl benzoate, imidazole, sodium hydroxide, phase transfer catalyst TEBA and dimethylformamide are mixed and stirred in the 9012. Add a proper amount of water and extract it with dichloromethane. The extract is concentrated, the residual liquid is added to sodium hydroxide solution for alkalization, and the reaction is carried out at 90 ℃. Acidification with concentrated hydrochloric acid, filtration precipitation, glacial acetic acid recrystallization. Dazolexobenzene hydrochloride. 51% yield.
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: Dazoxiben Request for quotationCAS: 78218-09-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: UK 37248 free base Visit Supplier Webpage Request for quotationCAS: 78218-09-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Dazoxiben Visit Supplier Webpage Request for quotation
CAS: 78218-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 78218-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Dazoxiben Request for quotationCAS: 78218-09-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: UK 37248 free base Visit Supplier Webpage Request for quotationCAS: 78218-09-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Dazoxiben Visit Supplier Webpage Request for quotation
CAS: 78218-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 78218-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Raw Materials for Dazoxiben
Acetic acid
Potassium carbonate
p-Toluenesulfonic acid
1,2-Dichloroethane
Ethylparaben
ETHYL 4-(2-CHLOROETHOXY)BENZOATE
Potassium carbonate
p-Toluenesulfonic acid
1,2-Dichloroethane
Ethylparaben
ETHYL 4-(2-CHLOROETHOXY)BENZOATE