Delamanid
Delamanid
CAS: 681492-22-8
Molecular Formula: C25H25F3N4O6
Delamanid - Names and Identifiers
Delamanid - Physico-chemical Properties
| Molecular Formula | C25H25F3N4O6 |
| Molar Mass | 534.48 |
| Density | 1.45 |
| Melting Point | 195-196℃ |
| Boling Point | 653.7±65.0 °C(Predicted) |
| Solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly, Sonicated) |
| Appearance | Solid |
| Color | Off-White to Light Yellow |
| pKa | 3.99±0.20(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Physical and Chemical Properties | The biological activity of Delamanid (OPC-67683) is a new type of anti-tuberculosis drug, which has good intracellular bactericidal activity and high accumulation rate in cells. |
| In vitro study | Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex. Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis. Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration. |
| In vivo study | Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL. |
Delamanid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.871 ml | 9.355 ml | 18.71 ml |
| 5 mM | 0.374 ml | 1.871 ml | 3.742 ml |
| 10 mM | 0.187 ml | 0.935 ml | 1.871 ml |
| 5 mM | 0.037 ml | 0.187 ml | 0.374 ml |
Last Update：2024-01-02 23:10:35
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View History
Delamanid
SYR-472 succinate
NSC525120
985-16-0
(3R)-morpholin-3-ylmethanol
METHAR HEXAHYDRATE
2-FORMYLMESITYLENE
Cetyldimethylethylammonium bromide
2,4-Dimethoxy
SYR-472 succinate
NSC525120
985-16-0
(3R)-morpholin-3-ylmethanol
METHAR HEXAHYDRATE
2-FORMYLMESITYLENE
Cetyldimethylethylammonium bromide
2,4-Dimethoxy