Developer,partB
Gluconic acid, sodium salt
CAS: 527-07-1
Molecular Formula: C6H13NaO7
Developer,partB - Names and Identifiers
| Name | Gluconic acid, sodium salt |
| Synonyms | glonsen Developer,partB Sodium gluconate SODIUM GLUCONATE RE Gluconic Acid Sodium SODIUM GLUCONATE pure SODIUM GLUCONATE REAGENT Gluconic acid sodium salt GLUCONIC ACID SODIUM SALT Gluconic acid, sodium salt D-Gluconic acid, monosodium salt D-Gluconate sodium salt, D-Gluconic acid sodium salt sodium 2,3,4,5,6-pentahydroxyhexanoate (non-preferred name) 2,3,4,5,6-Pentahydroxycaproic acid sodium salt, D-Gluconate sodium salt, Sodium D-gluconate 2,3,4,5,6-Pentahydroxycaproic acid sodium salt, D-Gluconate sodium salt, D-Gluconic acid sodium salt, Sodium D-gluconate |
| CAS | 527-07-1 |
| EINECS | 208-407-7 |
| InChI | InChI=1/C14H14O3.C6H12O7.Na/c1-8(2)7-11(15)12-13(16)9-5-3-4-6-10(9)14(12)17;7-1-2(8)3(9)4(10)5(11)6(12)13;/h3-6,8,12H,7H2,1-2H3;2-5,7-11H,1H2,(H,12,13);/q;;+1/p-1/t;2-,3-,4+,5-;/m.1./s1 |
Developer,partB - Physico-chemical Properties
| Molecular Formula | C6H13NaO7 |
| Molar Mass | 220.15 |
| Melting Point | 170-175 °C |
| Specific Rotation(α) | [α]D20 +11～+13° (c=10, H2O) |
| Water Solubility | Very soluble in water; sparingly soluble in alcohol; insoluble in ether. |
| Solubility | Soluble in water (25 ℃,59g/100mL), slightly soluble in ethanol, insoluble in ether. |
| Appearance | White bright yellow crystal |
| Color | White to light beige |
| Merck | 14,4456 |
| BRN | 3919651 |
| PH | 7.0-8.0 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| MDL | MFCD00064210 |
| Physical and Chemical Properties | Properties: White crystalline granules or powder, very soluble in water, slightly soluble in alcohol, insoluble in ether. |
| Use | Food additives, electroplating complexing agents, water quality stabilizers, printing and dyeing industry colorants, steel surface treatment agents |
Developer,partB - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | LZ5235000 |
| TSCA | Yes |
| HS Code | 29181600 |
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
Developer,partB - Upstream Downstream Industry
Developer,partB - Reference
| Reference Show more | 1. [IF=4.411] Datong Hu et al.Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata.Molecules. 2021 Jan;26(23):7116 |
Developer,partB - Nature
Open Data Verified Data
white or pale yellow crystalline powder. There is a fragrant taste. The solubility in water is 60% at 20 °c, 85% at 50 °c, 133% at 80 °c, and 100 at 160% °c. Slightly soluble in alcohol, insoluble in ether. Heating to boiling in water will not decompose in a short period of time. The stability of the chelate with metal ions increases with the increase of pH value.
Last Update：2025-06-10 22:55:16
Developer,partB - Preparation Method
Open Data Verified Data
in the industry, glucose-containing substances (e. G., grains) are used as raw materials, and sodium gluconate is prepared by fermentation method by first preparing gluconic acid from glucose and then neutralizing with sodium hydroxide. Gluconic acid can also be prepared from glucose by chemical oxidation or catalytic oxidation, but the yield is low and purification is difficult.
Last Update：2025-06-10 22:55:16
Developer,partB - Introduction
The aqueous solution is stable when it is just boiled.
Last Update：2022-10-16 17:25:54
Developer,partB - Application
Open Data Verified Data
sodium gluconate is a polyhydroxy acid type corrosion and scale inhibitor, which has excellent coordination ability to iron, calcium and copper plasma in aqueous solution, and many of the salts of these ions have a very good detergent effect. Not only has the function of scale inhibition, but also has the function of corrosion inhibition. It can be used for industrial circulating cooling water, water treatment in low-pressure boilers and water treatment in internal combustion engine cooling water systems. It can be combined with many corrosion inhibitors, and show synergistic effect, suitable for silicon, molybdenum, phosphorus, boron, tungsten, nitrite and some organic corrosion inhibitor series, sodium gluconate and organic carboxylic acid also have a good synergistic effect on corrosion inhibition. Is a green multi-functional water treatment chemicals. The composition of the alkaline cleaning formula can be used as a metal surface scale and rust removal, cement rapid setting of the inhibitor, textile processing aids and metal ion carriers.
Last Update：2025-08-19 16:24:40
Developer,partB - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | sodium gluconate is a common and widely used sodium salt of organic acid. Industrial-grade sodium gluconate is often used in construction, chemical and other industries. In the construction industry, it is often used as a cement additive to reduce water and retarding. In the chemical industry, it is used as the production of other gluconate and gluconate. The basic raw material of acid and gluconolactone, also has good applications in electroplating, cleaning agent, film manufacturing, water quality treatment, etc; food-grade gluconic acid sodium is commonly used in the food and pharmaceutical industries. In the food industry, as a food additive, it plays a role in regulating taste, regulating acidity, dehydration, curing, etc. In the pharmaceutical industry, it can regulate acid-base balance and maintain extracellular osmotic pressure. |
| main uses | sodium gluconate is widely used in food and industry. sodium gluconate can be used as high-efficiency chelating agent in construction, textile printing and dyeing, metal surface treatment, water treatment and other industries, steel surface cleaning agent, glass bottle cleaning agent, aluminum-oxygen coloring in electroplating industry, and as high-efficiency retarder and high-efficiency water reducing agent in concrete industry. Used in food industry sodium gluconate can replace table salt: the salt taste of sodium gluconate is close to table salt, while the molecular weight of sodium accounts for only 10.5%. compared with table salt, the sodium content of the former is only 1/4 of that of the latter. And compared with other low-sodium salts, sodium gluconate has the advantages of non-irritating, no bitter taste, and pungent salt, and has become the best substitute for salt. At present, it is widely used in salt-free soy sauce, bread and other food fields. In white bread, sodium gluconate completely replaces sodium chloride, which will not cause the difference in the volume of the bread, and will not affect its overall flavor and shelf life. sodium gluconate can improve food flavor: sodium gluconate has the effects of masking food bitterness, shielding peculiar smell, improving taste, etc., and has significant effect on improving food flavor. By adding sodium gluconate to the low-fat cheese, the original bitter and astringent taste of the low-fat cheese is eliminated, and the overall taste is improved. By comparing the flavor of lactone tofu made by sodium gluconate and gypsum as coagulant, it is found that the tofu pointed out with sodium gluconate is more tender and has higher taste and nutritional value. Sodium gluconate can enhance the nutritional properties of food: it can enhance the nutritional properties of food. For example, through in-depth research on the hardening phenomenon of cheese, it is found that sodium gluconate can form a soluble complex with calcium ions and lactic acid ions in cheese, thereby increasing the solubility of calcium lactate, which not only effectively prevents cheese from hardening, but also ensures the nutritional quality of cheese. Used as cleaning agent for steel surface If the steel surface needs to be plated with pot, chrome, tin and nickel to adapt to special purposes, such as manufacturing tinplate, galvanized sheet, chrome plating (electroplating) on the surface, the billet surface needs to be strictly cleaned to make the coating firmly combine with the steel surface. At this time, adding sodium gluconate to the cleaning agent will achieve a very ideal effect. Used as cement admixture After adding a certain amount of sodium gluconate to cement, it can increase the plasticity and strength of the concrete, and has a blocking effect, that is, delaying the initial and final setting time of the concrete; used as a special cleaning agent for glass bottles The professional cleaning agent for glass bottles with sodium gluconate as the main formula can improve the following common problems: the detergency is not strong, and it is easy to block the nozzles and pipelines of the bottle washer; the stain removal power of bottle sticking and bottleneck rust is not ideal. Trace residues after washing are not ideal for edible safety (such as phosphate residues); Washing water is discharged into a public hazard. Used as water quality stabilizer because sodium gluconate has excellent corrosion and scale inhibition effect, it is widely used as water quality stabilizer, such as circulating cooling water system of petrochemical enterprises, low pressure boiler, cooling water system of internal combustion engine and other treatment agents. Because it has the following specific advantages: (1) it has obvious coordination effect. It is suitable for molybdenum, silicon, phosphorus, tungsten, nitrite and other formulas. Due to the coordination effect, the corrosion inhibition effect is greatly improved. ⑵ The corrosion inhibition rate increases with the increase of temperature. Generally, the corrosion inhibitor decreases with the increase of temperature, or even loses its effect completely. However, sodium gluconate is on the contrary, and the corrosion inhibition rate increases with the increase of temperature within a certain range. (3) Strong scale inhibition ability: It has strong complexation ability for calcium, magnesium and iron salts, so it has strong scale inhibition ability, especially for Fe3 +, which has excellent chelation effect, and even has effect in the whole PH range. (4) Extinct public nuisance. Sodium gluconate is used as a corrosion and scale inhibitor for circulating cooling water to eliminate public hazards, which is an incomparable advantage of other corrosion and scale inhibitors currently used. |
| content analysis | accurately weigh about 750mg of the sample, transfer it into a dry 200ml conical flask, add 75ml of glacial acetic acid, heat and dissolve on a heating plate, cool it, add several drops of quinalidine red test solution (TS-203), titrate with 0.1mol/L perchloric acid glacial acetic acid solution through 10ml of microburette to colorless end point. Perchloric acid is equivalent to sodium gluconate (C6H11NaO7)21.81mg per ml of 0.1mol/L. |
| toxicity | ADI does not make special regulations (calculated as gluconic acid, FAO/WHO,2001). GRAS(FDA,§ 182.6757,2000). |
| use limit | is limited to GMP (FDA,§ 182.6757,2000). |
| use | as brightener in nickel-iron alloy electroplating. Single use has the advantages of clarifying the plating solution, bright surface of the plating part, fine crystallization and good leveling, and the dosage is 0.1~0.2g/l. food additives, electroplating complexing agent, water quality stabilizer, printing and dyeing industry color reagent, steel surface treatment agent, etc. used in pharmaceutical industry used as corrosion and scale inhibitor for circulating cooling water system, used for electroplating and metal cleaning, also used in pharmaceutical nutritional supplement, chelating agent, yeast food. As a scale and corrosion inhibitor in industrial water treatment, it has a good effect with aluminum. |
| production method | add metered calcium gluconate into the reaction kettle, and add sulfuric acid aqueous solution under stirring. After stirring for 1h, stand for filtration, and the filter residue is CaSO4, which is removed. The filtrate is added to the neutralization kettle, and an appropriate amount of Na2CO3 aqueous solution is added for neutralization. Concentrate, filter, dry, and inspect qualified packaged finished products. It is obtained by neutralizing with sodium base after glucose fermentation. the metered gluconic acid was added into the reaction kettle, and slightly excessive Na2CO3 aqueous solution was added under stirring to neutralize, and stirred at 50~60 ℃ for 2 h. Concentrate under reduced pressure, cool, crystallize, filter and dry to obtain the finished product. |
| spontaneous combustion temperature | >200°C |
Last Update：2024-04-09 21:11:58
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