Dihexa
Dihexa
CAS: 1401708-83-5
Molecular Formula: C27H44N4O5
Dihexa - Names and Identifiers
Dihexa - Physico-chemical Properties
| Molecular Formula | C27H44N4O5 |
| Molar Mass | 504.66 |
| Density | 1.111±0.06 g/cm3(Predicted) |
| Melting Point | >209°C (dec.) |
| Boling Point | 866.2±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 30 mg/mL |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 9.83±0.15(Predicted) |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
| Physical and Chemical Properties | Appearance: white powder |
| Use | Sequence: Hexanoyl-Tyr-Ile-Ahx-NH2 |
| In vitro study | Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met. |
| In vivo study | Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons. |
Dihexa - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.982 ml | 9.908 ml | 19.815 ml |
| 5 mM | 0.396 ml | 1.982 ml | 3.963 ml |
| 10 mM | 0.198 ml | 0.991 ml | 1.982 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.396 ml |
Last Update：2024-01-02 23:10:35
Dihexa - Reference Information
| Biological activity | Dihexa (PNB-0408), an oligopeptide reagent, is an angiotensin IV analog with oral activity and permeability of the blood-brain barrier. Dihexa binds hepatocyte growth factor (HGF) with high affinity with a Kd value of 65 pM and enhances its activity against receptor c-Met. Dihexa showed excellent antipsychotic activity and improved cognitive function in animal models. Dihexa has the potential to study Alzheimer's. |
| target | Kd: 65 pM (HGF) |
| in vitro study | dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV inuce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met. |
| in vivo study | Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons. |
Last Update：2024-04-09 21:54:55
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Product Name: N-((S)-1-(((2S,3S)-1-((6-Amino-6-oxohexyl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)hexanamide Request for quotationCAS: 1401708-83-5
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Product Name: Dihexa Request for quotationCAS: 1401708-83-5
Tel: +86-21-56795779
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Mobile: +86-13651600618
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Product Name: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2 Visit Supplier Webpage Request for quotationCAS: 1401708-83-5
Tel: 609-228-6898
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Product Name: Dihexa Visit Supplier Webpage Request for quotation
CAS: 1401708-83-5
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CAS: 1401708-83-5
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Email: 3008007409@qq.com
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Product Name: Dihexa Request for quotation
CAS: 1401708-83-5
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QQ: 1761863581Send QQ message
CAS: 1401708-83-5
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Email: qilin@cellmano.com
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