Diisopropylamine
Diisopropylamine
CAS: 108-18-9
Molecular Formula: C6H15N
Diisopropylamine - Names and Identifiers
| Name | Diisopropylamine |
| Synonyms | Diisopropylamin Diisopropylamine 2-isopropylamine Di-iso-propylamine Bis(isopropyl)amine N,N-Diisopropylamine N-(propan-2-yl)propan-2-amine N-(1-Methylethyl)-2-propamine n-(1-methylethyl)-2-propanamin dipropylamine(non-specificname) (N-(1-Methylethyl)-2)propanamine N-(1-methylethyl)propan-2-aminium N-Isopropyl-1-amino-2-methylethane |
| CAS | 108-18-9 |
| EINECS | 203-558-5 |
| InChI | InChI=1/C6H15N/c1-5(2)7-6(3)4/h5-7H,1-4H3/p+1 |
| InChIKey | UAOMVDZJSHZZME-UHFFFAOYSA-N |
Diisopropylamine - Physico-chemical Properties
| Molecular Formula | C6H15N |
| Molar Mass | 101.19 |
| Density | 0.722 g/mL at 25 °C (lit.) |
| Melting Point | -61 °C (lit.) |
| Boling Point | 84 °C (lit.) |
| Flash Point | 1.4°F |
| Water Solubility | 100 g/L (20 ºC) |
| Solubility | 100 g/L (20°C) |
| Vapor Presure | 50 mm Hg ( 20 °C) |
| Vapor Density | 3.5 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless |
| Odor | Amine. |
| Exposure Limit | NIOSH REL: TWA 5 ppm (20 mg/m3), IDLH 200 ppm; OSHA PEL: TWA 5ppm; ACGIH TLV: TWA 5 ppm (adopted). |
| Merck | 14,3196 |
| BRN | 605284 |
| pKa | 11.05(at 25℃) |
| PH | 11.8 (6g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents. May react violently with strong acids or oxidizers. Air sensitive. |
| Explosive Limit | 1.1-7.1%(V) |
| Refractive Index | n20/D 1.392(lit.) |
| Physical and Chemical Properties |
|
| Use | Used as rubber accelerator, pharmaceutical intermediates, pesticides, herbicides, surfactants, etc. Used as a stroke agent, polymerization of the catalytic Accelerator. Also used in the manufacture of pharmaceuticals, pesticides, rubber vulcanization accelerator, surfactant. Diisopropylamine nitrite is used as a steel preservative. |
Diisopropylamine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R20/22 - Harmful by inhalation and if swallowed. R34 - Causes burns |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1158 3/PG 2 |
| WGK Germany | 2 |
| RTECS | IM4025000 |
| TSCA | Yes |
| HS Code | 2921 19 99 |
| Hazard Note | Highly Flammable/Corrosive/Harmful |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in rats: 0.77 g/kg (Smyth) |
Diisopropylamine - Upstream Downstream Industry
| Raw Materials | Hydrogen Ammonia Isopropanol Isopropanol |
| Downstream Products | gemfibrozil |
Diisopropylamine - Nature
Open Data Verified Data
colorless transparent volatile liquid, flammable, ammonia odor, strong alkaline. Soluble in a variety of organic solvents. The relative density was 0.7178. Melting Point -61 °c. Boiling point 83. 90 °c. Refractive index 3924. Flash point (Open Cup)-17 °c. Vapor pressure (20 °c) 8.0 kPa.
Last Update：2025-06-10 22:55:16
Diisopropylamine - Preparation Method
Open Data Verified Data
- acetone is mixed with a certain amount of ammonia and hydrogen after acetone is gasified by catalytic hydrogenation and amination, and the catalytic reaction is carried out continuously at normal pressure and appropriate temperature. The catalyst is Ni_Cu-clay, the reaction product is subjected to rectification and fractionation to obtain a finished product.
- isopropyl alcohol catalytic hydrogenation amination isopropyl alcohol, liquid ammonia, hydrogen mixed in gas phase according to a certain proportion, in the presence of catalyst C u-Ni-clay, synthesis of diisopropylamine crude, after extraction, separation, dehydration, distillation to obtain the finished product.
Last Update：2022-01-01 10:35:05
Diisopropylamine - Application
Open Data Verified Data
This product is an organic synthetic raw material, which is mainly used for the synthesis of pesticide herbicide oat enemy 1, 2, synthetic medicine ganle, viproamine, nippine and prubenxin, etc. It is also used for the synthesis of dyes, rubber vulcanization accelerator, surfactant, detergent and Defoamer, etc.
Last Update：2025-08-19 16:24:40
Diisopropylamine - Safety
Open Data Verified Data
- This product is toxic. Liquid or vapor can irritate the skin, eyes, respiratory tract, and lungs. Start 2~5 minutes after the onset of salivation and tears, sneezing, Cough, after tremor, cramps, collapse. Its toxicity is greater than that of methylamine and ethylamine. Rat oral LD50 770mg/kg. Splash and flush the skin with plenty of water. The maximum allowable concentration at the operating site is 5 mg/m3. Under the conditions of production, if people inhaled this product 0.2~0. 5mg/L, after 2~3 hours, that is, blurred vision, Head Pain and Nausea. Protective equipment should be worn during operation to ensure safety.
- This product is a general flammable liquid. Packed in iron drum, 170kg per barrel, to prevent damage and leakage of the container. Store in a cool and ventilated place, away from the fire source, should be stored with the oxidant Isolation.
Last Update：2022-01-01 10:35:06
Diisopropylamine - Reference Information
| LogP | 0.4 at 20℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | diisopropylamine is an intermediate of the herbicide fiyandiamine and a raw material for the production of the insecticide imidacloprid. used as rubber vulcanization accelerator, pharmaceutical intermediates, dyes, pesticides, herbicides, emulsifiers, detergents, surfactants, etc. Also used as a stroke agent, the polymerization of the catalytic promoter. Diisopropylamine nitrite is used as a steel preservative. diisopropylamine is a commonly used raw material for organic synthesis, which is mainly used for the synthesis of pesticide herbicide oat enemies 1 and 2, and for the synthesis of pharmaceutical drugs such as ganle, vipropylamine, nippine and prubenxin, etc. It is also used for the synthesis of dyes, rubber accelerator, mineral flotation agent, detergent, Defoamer, emulsifier, latex floor paint base material and other surfactant products. |
| production method | is obtained by hydrogenation and Amination of acetone or isopropanol. 1. Acetone catalytic hydrogenation ammoniation acetone gasification after mixed with a certain amount of ammonia and hydrogen, under normal pressure and appropriate temperature, continuous catalytic reaction, catalyst for Ni-Cu-clay, reaction products by distillation, fractionation, to obtain the finished product. Raw material consumption quota: acetone 1389kg/t, liquid ammonia 376kg/t, hydrogen (99%)1023. 2. Isopropyl alcohol catalytic hydrogenation amination isopropyl alcohol, liquid ammonia, hydrogen in gas phase according to a certain proportion of mixed, in the presence of catalyst Cu-Ni-clay, synthesis of diisopropylamine crude, after extraction, separation, dehydration, the finished product was obtained by distillation. The total conversion was 86% and the yield was 96%. Containing isopropylamine 37%, diisopropylamine 33%, isopropanol 12%, water 18%, isopropylamine and diisopropylamine were isolated, and the unreacted isopropanol was recycled. The proportion of the product can be changed by adjusting the ratio of isopropyl alcohol and ammonia. The preparation method is based on acetone, ammonia and hydrogen as raw materials, in the atmospheric pressure 150~220 ℃ with nickel, copper, Clay as catalyst, acetone conversion rate of 98%, the crude monoisopropylamine and diisopropylamine were obtained, respectively, by distillation. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-mouse LD50:2120 mg/kg; Inhalation-rat LC50:4800 mg/m3/2 h |
| stimulation data | Skin-rabbits 500 mg/24 h mild; eye-rabbit 750 mcg severe |
| explosive hazard characteristics | explosive when mixed with air |
| flammability hazard characteristics | in case of fire, high temperature, oxidant flammable; toxic NOx smoke from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| Occupational Standard | TWA 20 mg/m3 |
| spontaneous combustion temperature | 599 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-and health-threatening concentration | 200 ppm |
Last Update：2024-04-09 21:04:16
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Raw Materials for Diisopropylamine
Downstream Products for Diisopropylamine