ET-1
endothelin 1
CAS: 117399-94-7
Molecular Formula: C109H159N25O32S5
ET-1 - Names and Identifiers
| Name | endothelin 1 |
| Synonyms | ET-1 ET-1, HUMAN endothelin 1 ET-1, HUMAN, PORCINE ET-1, HUMAN AND PORCINE Endothelin 1 human, porcine ENDOTHELIN-I, HUMAN, PORCINE ET-1 (HUMAN, PORCINE, DOG, RAT) Endothelin 1, Human and Porcine ET-1 (HUMAN, MOUSE, RAT, PIG, BOVINE, DOG) ET-1 (HUMAN, BOVINE, DOG, MOUSE, PORCINE, RAT) |
| CAS | 117399-94-7 |
| InChI | InChI=1/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166) |
ET-1 - Physico-chemical Properties
| Molecular Formula | C109H159N25O32S5 |
| Molar Mass | 2491.9 |
| Density | 1.273±0.06 g/cm3(Predicted) |
| Boling Point | 2467.3±65.0 °C(Predicted) |
| Water Solubility | Soluble in water. |
| Solubility | 1% acetic acid: >1mg/mL |
| Appearance | White powder |
| Color | white |
| Merck | 13,3610 |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| MDL | MFCD00133305 |
| Use | Synthetic peptides with human and porcine endothelin-1 sequences. The biological source is a potent agonist of the human endothelin ETA and ETB endothelin receptors with the same sequence. Induction of hypoxia-inducible factor-1α production of vascular endothelial growth factor. |
| In vitro study | Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. |
ET-1 - Risk and Safety
| WGK Germany | 3 |
| RTECS | KE9446500 |
| FLUKA BRAND F CODES | 3-10 |
ET-1 - Reference
| Reference Show more | 1. Han Lan Ji Zhaojie Chen Weidong et al. Neuroprotective effect of Siwu Decoction on vascular dementia rats and its mechanism [J]. Journal of Anhui University of Traditional Chinese Medicine 2015 34(4):69-73. |
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