Name | Eprinomectin |
Synonyms | eprinex Eprinomectin EPRINOMECTIN EprinomectinB1 EPRINOMECTIN VETRANAL Emamectin B1 Benzoate EPRINOMECTIN VETRANAL Avermectin B1, 4-(acetylamino)-4-deoxy-, (4R)- (4''R)-4''-(ACETYLAMINO)-4''-DEOXY-AVERMECTIN B1 (4''r)-4''-(acetylamino)-4''-deoxy-avermectin b1solution (2aZ,4Z,5'S,6S,6'R,7S,8Z,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-(1-methylethyl)-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 4-O-[4-(acetylamino)-2,4,6-trideoxy-3-O-methyl-α-L-xylo-hexopyranosyl]-2,6-dideoxy-3-O-methyl-α-L-lyxo-hexopyranoside |
CAS | 123997-26-2 |
EINECS | 602-966-4 |
InChI | InChI=1/C50H75NO14/c1-12-26(2)45-29(5)18-19-49(65-45)24-36-21-35(64-49)17-16-28(4)44(27(3)14-13-15-34-25-58-47-43(53)30(6)20-37(48(54)61-36)50(34,47)55)62-41-23-39(57-11)46(32(8)60-41)63-40-22-38(56-10)42(31(7)59-40)51-33(9)52/h13-16,18-20,26-27,29,31-32,35-47,53,55H,12,17,21-25H2,1-11H3,(H,51,52)/b14-13+,28-16+,34-15+/t26-,27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43+,44-,45+,46-,47+,49+,50+/m0/s1 |
Molecular Formula | C50H75NO14 |
Molar Mass | 914.1288 |
Density | 1.23 |
Melting Point | 163-166°C |
Flash Point | 2°C |
Appearance | neat |
Storage Condition | 2-8°C |
Refractive Index | 1.567 |
Physical and Chemical Properties | Melting point 163-166°C density 1.23 flash point 2°C storage conditions 2-8°C |
Risk Codes | R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R62 - Possible risk of impaired fertility R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R25 - Toxic if swallowed R63 - Possible risk of harm to the unborn child |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2811 |
WGK Germany | 3 |
HS Code | 2941906000 |
Toxicity | LD50 orally in mice: 24 mg/kg (Jones) |
Reference Show more | 1. [IF=7.658] Xuan Zhang et al."Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects."Pharmacol Res. 2020 Jun;156:104763 |
introduction | epp is the latest avermectin anthelmintic, which is formed by introducing acetamide group at the 4 "end of avermectin. Like other avermectins, Epmectin is effective against most nematodes and arthropod insects. |
properties | ampamycin sulfate is yellow or yellow-brown powder, hygroscopic, and soluble in water. |
Mechanism of action | Epsin is a macrolide antiparasitic drug, which has a repellent effect on nematodes and arthropods. Its repellent principle is to increase the inhibitory transmitter of worms. The release of gamma-aminobutyric acid (GABA), and the opening of the Cl ion channel controlled by glutamate, which enhances the permeability of the nerve membrane to Cl, thereby blocking the transmission of nerve signals, in the end, nerve paralysis causes muscle cells to lose their ability to contract, which leads to the death of the worm. |
biological activity | Eprinomectin (EPM, MK-397) is an excellent broad-spectrum fungicide with anti-worm, insecticidal and acaricidal activities. |
use | is an efficient, broad-spectrum and low-residue antiparasitic drug used to prevent parasitic diseases of livestock (especially during lactation) |