Euphol
Euphol
CAS: 514-47-6
Molecular Formula: C30H50O
Euphol - Names and Identifiers
Euphol - Physico-chemical Properties
| Molecular Formula | C30H50O |
| Molar Mass | 426.72 |
| Density | 0.98±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 116-117℃ |
| Boling Point | 498.9±44.0 °C(Predicted) |
| Specific Rotation(α) | (CHCl3)+32 |
| Solubility | Easily soluble in n-hexane, chloroform, methanol |
| Appearance | White powder |
| pKa | 15.16±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD01716323 |
| Physical and Chemical Properties | White powder, easily soluble in n-hexane, chloroform, methanol, derived from Kansui, Beijing Euphorbia. |
| In vitro study | Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC 50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins. Cell Proliferation Assay Cell Line: T47D cells Concentration: 0.01, 0.03, 0.1 and 0.3 mM Incubation Time: 24, 48 and 72 hours Result: Decreased the percentage of viable cells. Western Blot Analysis Cell Line: T47D cells Concentration: 0.03 mM Incubation Time: 48 and 72 hours Result: Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D. |
Euphol - Reference
| Reference Show more | 1. [IF=5.11] Weibo Qiao et al."De Novo Biosynthesis of the Anticancer Compound Euphol in Saccharomyces cerevisiae."Acs Synth Biol. 2021;10(9):2351–2358 2. [IF=3.935] Wenting Zhang et al."Screening and identification of Euphorbiae pekinensis Rupr. anti-angiogenic multi-components with UPLC-QTOF-MS in zebrafish."J Pharmaceut Biomed. 2022 Jan;207:114396 |
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