Evodiamine
Evodiamine
CAS: 518-17-2
Molecular Formula: C19H17N3O
Evodiamine - Names and Identifiers
| Name | Evodiamine |
| Synonyms | Evodiamine Evodiaminel d-Evodiamine (+)-Evodiamine Evodiamine, (+)- Evodia rutaecarpa E.P. EvodiaMine(IsoevodiaMine) 8,13,13b,14-tetrahydro-14-methyl-,(S)- |
| CAS | 518-17-2 |
| EINECS | 637-111-4 |
| InChI | InChI=1/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3/t18-/m0/s1 |
| InChIKey | TXDUTHBFYKGSAH-UHFFFAOYSA-N |
Evodiamine - Physico-chemical Properties
| Molecular Formula | C19H17N3O |
| Molar Mass | 303.36 |
| Density | 1.1684 (rough estimate) |
| Melting Point | 278° |
| Boling Point | 444.29°C (rough estimate) |
| Specific Rotation(α) | D15 +352° (acetone); D +440° (chloroform) |
| Flash Point | 301.6°C |
| Solubility | Soluble in acetone, slightly soluble in ethanol, ether, chloroform, almost insoluble in water, petroleum ether, benzene |
| Vapor Presure | 3.15E-13mmHg at 25°C |
| Appearance | White needle crystal (chloroform) |
| Color | Yellow |
| pKa | 17.27±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.5900 (estimate) |
| MDL | MFCD06407824 |
| Physical and Chemical Properties | Soluble in acetone, slightly soluble in ethanol, ether, chloroform, almost insoluble in water, petroleum ether, benzene. Evodia rutaecarpa (Juss.) Benth, a rutaceae plant. The near-mature fruit. |
Evodiamine - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29339900 |
Evodiamine - Reference
| Reference Show more | 1. Zhang Wei, Yilin, Shuxian, Houhua et al. Effects of total alkaloids from Evodia on left ventricular hypertrophy and calcineurin signaling pathway in rats [J]. Journal of Zunyi Medical College, 2014, 37(002):151-155. 2. Gu, Jia, Yu, Dan, Dan, Rui-Guang. Interaction between evodiamine and Liposome biomembrane: FTIR and DSC studies [J]. Spectroscopy and spectral analysis 2019 39(006):1757-1762. 3. Cao Zhi, Yang Yilin, Wang suiwen et al. Effect of evodiamine on proliferation and apoptosis of human glioma U251 cells [J]. Journal of Clinical Neurosurgery 2014. 4. Zhang Hong, Mei Li, Guo, Song long, et al. Pharmacognostical identification of fructus evodiae and its pseudo-product on the fruit of aromatic and hot trees [J]. Chinese herbal medicine 2016 (phase 3):515-518. 5. Zhang Hongmei, Li Guo, Song long, et al. Fingerprint analysis and content determination of fructus evodiae from Guizhou and Zhejiang [J]. Chinese Journal of Experimental prescriptions, 2014, 20(017):69-73. 6. Liu Lu, Wang Xuemei, Wang Yan, Xi Hongmei, Guo jiando, Huang Qiujin. Promoting Effect of evodiamine on apoptosis of glioma SHG-44 cells and its mechanism [J]. Journal of Chinese Academy of Medical Sciences, 2020,42(05):591-595. 7. Xu Guobo, Lei Dandan, Xiao Yaohua, Chen Guanggui, He Xun, Liao Shanggao. Study on characteristic fingerprint of liangjiangweiyang capsule by HPLC [J]. Central South pharmacy, 2020,18(09):1503-1507. 8. Zhou Jianxin, Shen Shuo, du maobo, Li Yujie, Sun Yi, He Aiping, Yao Yao, Wang Mingsuo, Liu Shuzhi, Yin Yongqin. Based on UPLC-Q-TOF-MS technology and integrated pharmacological methods to explore the molecular mechanism of the transdermal components of Evodia and its treatment of Diarrhea [J]. Chinese Journal of Experimental prescriptions, 2021,27(07):112-120. 9. Chen Yongshun, Yang Jinxia, Wu Zhen. Preparation and quality evaluation of evodiamine hydrogel patch [J]. China pharmacist, 2021,24(03):571-574. 10. Zhang Y, Wang J, Wang C, Li Z, Liu X, Zhang J, Lu J, Wang D. Pharmacological Basis for the Use of Evodiamine in Alzheimer's Disease: Antioxidation and Antiapoptosis. International Journal of Molecular Sciences. 2018; 19(5):1527. https://doi.org/10.3390/ijm 11. [IF=4.183] Yongfeng Zhang et al."Pharmacological Basis for the Use of Evodiamine in Alzheimer's Disease: Antioxidation and Antiapoptosis."Int J Mol Sci. 2018 May;19(5):1527 12. [IF=4.432] Zhijun Zhao et al."Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum."Eur J Pharmacol. 2021 Oct;908:174340 13. [IF=2.952] Yongfeng Zhang et al."Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects."Mol Med Rep. 2022 May;25(5):1-14 14. [IF=4.05] Xingming Hou et al."Evodiamine Lowers Blood Lipids by Up-Regulating the PPARγ/ABCG1 Pathway in High-Fat-Diet-Fed Mice."J Nat Prod. 2021;XXXX(XXX):XXX-XXX |
Evodiamine - Introduction
Pharmacological effects: evodiamine has the effects of invigorating the stomach, analgesia, stopping retching and stopping acid; it has a diuretic effect; it has a strong inhibitory effect on E. coli; it has a significant insecticidal effect on Ascaris suis; it also contracts the uterus And the effect of pressure. It is effective in treating Alzheimer's disease and stroke.
Last Update：2022-10-16 17:25:47
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