Feprazone
Feprazone
CAS: 30748-29-9
Molecular Formula: C20H20N2O2
Feprazone - Names and Identifiers
| Name | Feprazone |
| Synonyms | Zepelin Feprazone Prenazone 250-324-3 methrazone pheprazone fenilprenazone phenylprenazone Feprazone (JAN) 4-(2-isopentenyl)-1,2-diphenyl-3,5-pyrazolidinedione 4-(b-Isoamylenyl)-1,2-diphenyl-3,5-pyrazolidinedione 1,2-diphenyl-4-(3-methyl-2-butenyl)-5-pyrazolidinedione 1,2-diphenyl-4-(3-methyl-2-butenyl)-3,5-pyrazolidinedione 3,5-Pyrazolidinedione, 4-(3-methyl-2-butenyl)-1,2-diphenyl- 4-(3-Methylbut-2-en-1-yl)-1,2-diphenylpyrazolidine-3,5-dione |
| CAS | 30748-29-9 |
| EINECS | 250-324-3 |
| InChI | InChI=1/C20H20N2O2/c1-15(2)13-14-18-19(23)21(16-9-5-3-6-10-16)22(20(18)24)17-11-7-4-8-12-17/h3-13,18H,14H2,1-2H3 |
Feprazone - Physico-chemical Properties
| Molecular Formula | C20H20N2O2 |
| Molar Mass | 320.39 |
| Density | 1.1670 (rough estimate) |
| Melting Point | 156.5° (ethanol) |
| Boling Point | 459.28°C (rough estimate) |
| Flash Point | 178.7°C |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Vapor Presure | 7.62E-08mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Yellow to Yellow |
| pKa | 5.09 ± 0.07(at 25℃) |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
| Refractive Index | 1.5700 (estimate) |
| Use | Anti-inflammatory drugs for the treatment of rheumatic and rheumatoid arthritis |
Feprazone - Risk and Safety
| Toxicity | LD50 in male mice, rats (mg/kg): 408.8, 386.4 i.p.; 1067, >2000 orally (Bianchi, Bonardi) |
Feprazone - Reference Information
| Overview | Non-steroidal anti-inflammatory and analgesic drugs. Its anti-inflammatory, antipyretic and analgesic effects are achieved by strongly inhibiting the synthesis of PG. The structural feature of feprazone is the introduction of isopentenyl group with anti-ulcer effect into the chemical structure, which not only retains the anti-inflammatory and analgesic effect, but also reduces the toxic and side effects, in particular, to avoid the adverse effect of similar drugs on the gastric mucosa. The efficacy of feprazone is about 10 times that of phenylbutazone and 30-50 times that of ibuprofen. Non-prazone was first listed in Italy in the Eighties, after the United Kingdom and Japan have also been produced. Treatment of rheumatoid arthritis, rheumatoid arthritis, periodontitis, scapulohumeral periarthritis, ankylosing spondylitis, thrombophlebitis, muscle fiber tissue inflammation and other diseases, pain effect is particularly good, the medical profession and patients with consistent high praise. By many clinical pharmacological tests show that its anti-inflammatory, analgesic effect is superior to ibuprofen, indomethacin, aspirin, methanoic acid and other similar drugs, long-term use of more special effects, is considered to be a safe, anti-inflammatory and analgesic drugs with definite curative effect and reasonable price. |
| pharmacokinetics | after oral administration, it is rapidly absorbed from the gastrointestinal tract and enters the blood to bind to plasma proteins, 4~6 hours blood drug concentration peak, plasma half-life (t1/2) for 24 hours. This product is converted in the body, in the form of metabolites excreted from the urine. |
| Use | the anti-inflammatory and antipyretic effects of non-prazosin are obvious, and it has good analgesic and antipyretic effects on inflammatory pain. Compared with hydrocortisone, phenylbutazone, mefenamic acid, indomethacin and the like, the anti-inflammatory effect thereof is equal to or superior. The analgesic effect is equivalent to an equal dose of phenylbutazone. Clinical application in rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, low back pain and muscle fiber inflammation, etc., the fastest improvement in pain is 2~3 days, generally 1~2 weeks to reduce, and Fever also have a certain effect. Anti-inflammatory drugs for the treatment of rheumatic and rheumatoid arthritis |
| drug interaction | This product is a non-steroidal anti-inflammatory analgesic drug, anti-inflammatory, antipyretic, the analgesic effect is achieved by a strong inhibition of the synthesis of PG. It is characterized by the introduction of functional pentenyl group with anti-ulcer effect in the chemical structure, which not only retains the anti-inflammatory and analgesic effect, but also reduces the toxic and side effects, in particular, to avoid the adverse effect of similar drugs on the gastric mucosa. |
Last Update：2024-04-10 22:40:09
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