GUGGULSTERONE
(Z)-Guggulsterone
CAS: 95975-55-6
Molecular Formula: C21H28O2
GUGGULSTERONE - Names and Identifiers
| Name | (Z)-Guggulsterone |
| Synonyms | Gugulipid GUGULSTERONE Guggulsterone CIS GUGGULSTERONE (Z)-Guggulsterone pregna-4,17-diene-3,16-dione Pregna-4,17-diene-3,16-dione PREGNA-4,17(20)-DIENE-3,16-DIONE (17Z)-pregna-4,17-diene-3,16-dione CIS-4,17(20)-PREGNADIENE-3,16-DIONE 4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE (17E)-Pregna-4,17(20)-diene-3,16-dione (8alpha,9beta,17E)-20-methoxypregna-4,17-diene-3,16-dione (8S,9R,10R,13S,14S,17E)-17-(1-methoxyethylidene)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione |
| CAS | 95975-55-6 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1 |
GUGGULSTERONE - Physico-chemical Properties
| Molecular Formula | C21H28O2 |
| Molar Mass | 312.45 |
| Density | 1.10±0.1 g/cm3(Predicted) |
| Boling Point | 463.3±45.0 °C(Predicted) |
| Flash Point | 172.3°C |
| Solubility | DMSO: 5 mg/mL |
| Vapor Presure | 9.21E-09mmHg at 25°C |
| Appearance | Pale yellow powder |
| Color | light yellow |
| Storage Condition | 2-8°C |
| Refractive Index | 1.557 |
GUGGULSTERONE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 37 - Irritating to the respiratory system |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29147000 |
GUGGULSTERONE - Reference Information
| biological activity | guggulster is a phytosterol derived from the gum of the commipora wightii tree. By down-regulating the anti-apoptosis gene product (IAP1,xIAP,Bfl-1/A1,Bcl-2,cFLIP,survivin), guggulster Regulates cyclin (cyclin D1,c-Myc), activation of caspases,JNK, inhibition of Akt, inhibition of growth of various tumor cells and induction of apoptosis. Guggulsterone mediates gene expression by regulating several transcription factors, including NF-κB,STAT3,C /EBPα, androgen receptors and glucocorticoid receptors. Guggulsterone, a farnesoid X receptor (FXR) antagonist, reduced CDCA-induced FXR activation with IC50 of 17 and 15 μm for Z-and E-Guggulsterone, respectively. |
| Cell Line: | RAW 264.7 murine macrophage cells |
| Concentration: | 0.5, 5, 10, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Suppressed TREM-1, TLR4, and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS. Improved the survival rates of wild-type mice with TNBS-induced colitis. |
| Animal Model: | Wild-type mice with TNBS-induced colitis |
| Dosage: | 100 mg/kg |
| Administration: | Orally; once per day; for 8 days |
Last Update：2024-04-09 20:52:54
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