Ganciclovir
Ganciclovir
CAS: 82410-32-0
Molecular Formula: C9H13N5O4
Ganciclovir - Names and Identifiers
| Name | Ganciclovir |
| Synonyms | GVC 2'-NDG Denosine Cytovene Ganciclovir GANCICILOVIR 2'-Nor-2'-deoxyguanosine 9-(1,3-Dihydroxy-2-propoxymethyl)guanine 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine GANCICLOVIR [9-(1,3-DIHYDROXY-2-PROPOXYMETHYL)GUANINE] 2-AMINO-9-((1,3-DIHYDROXYPROPAN-2-YLOXY)METHYL)-1H-PURIN-6(9H)-ONE 2-AMINO-1,9-[[2-HYDROXY-1-(HYDROXYMETHYL)ETHOXY]METHYL]6H-PURIN-6-ONE 2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one 2-AMINO-1,9-[[2-HYDROXY-1-(HYDROXYMETHYL)ETHOXY]METHYL]6H-PURIN-6-ONE(GANCICLOVIR) |
| CAS | 82410-32-0 |
| EINECS | 627-054-3 |
| InChI | InChI=1/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) |
| InChIKey | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
Ganciclovir - Physico-chemical Properties
| Molecular Formula | C9H13N5O4 |
| Molar Mass | 255.23 |
| Density | 1.3559 (rough estimate) |
| Melting Point | 250°C |
| Boling Point | 398.46°C (rough estimate) |
| Flash Point | 9℃ |
| Water Solubility | 3.6g/L(25 ºC) |
| Solubility | 0.1M HCl |
| Appearance | White powder |
| Color | white |
| Merck | 14,4363 |
| pKa | 9.33±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.7610 (estimate) |
| MDL | MFCD00870588 |
| Physical and Chemical Properties | Crystallization from methanol, melting point 250 ℃ (decomposition); There are also reports of monohydrate obtained from water, melting point 248-249 ℃ (decomposition); Crystallization from water, melting point> 300 °c UV maximum absorption (methanol):254nm (Φ12880). Solubility in water at 25 ° C.: 4.3mg/Ml at Ph = 7 Acute toxicity LD50 mice (g/kg):1~2 intraperitoneal injection. |
| Use | Anti-Virus, for the treatment of Cytomegalovirus Virus (CMV) infections due to immunocompromised |
Ganciclovir - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R46 - May cause heritable genetic damage R60 - May impair fertility R61 - May cause harm to the unborn child |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | MF8407000 |
| HS Code | 29335990 |
| Toxicity | LD50 i.p. in mice: 1-2 g/kg (Martin) |
Ganciclovir - Standard
Authoritative Data Verified Data
This product is 9-[[2-hydroxy-l-(hydroxymethyl) ethoxy] methyl] guanine. The content of C9H13N504 shall not be less than 99.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
Ganciclovir - Trait
Authoritative Data Verified Data
- This product is a white crystalline powder; Odorless; Has hygroscopicity.
- This product is slightly soluble in water or glacial acetic acid, almost insoluble in methanol, insoluble in methane; Slightly soluble in hydrochloric acid solution or sodium hydroxide solution.
Last Update：2022-01-01 11:56:17
Ganciclovir - Differential diagnosis
Authoritative Data Verified Data
- take an appropriate amount of this product, add water to dissolve and dilute to prepare a solution containing about 10ug per lml, and measure it by UV-Vis spectrophotometry (General rule 0401), there is a maximum absorption at a wavelength of 252MN; There is a minimum absorption at a wavelength of 222nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1266). If there is any difference, take an appropriate amount of this product and the reference product, add water separately to make saturated solution, filter, take the filtrate below 10°C overnight, wait for crystallization, filter, filter, filter residue after drying at 105°C, assay again.
Last Update：2022-01-01 11:56:17
Ganciclovir - Exam
Authoritative Data Verified Data
Related substances
Take 15mg of this product, put it in a 50ml measuring flask, add 1ml of 0.4% sodium hydroxide solution to dissolve it, dilute it with mobile phase to scale, shake well, and use it as a test solution. Take 1ml for precision measurement, set in a 100ml measuring flask, dilute to the scale with the mobile phase, and shake to serve as a control solution. According to high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane was used as filler; Methanol-water (5:95) was used as mobile phase; Detection wavelength was 252nm; the number of theoretical plates is not less than 3000 according to the ganciclovir peak. 20ul of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 6.0% (General rule 0831).
ignition residue
This product l.O g, inspection according to law (General 0841), residue shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:56:18
Ganciclovir - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add glacial acetic acid 40ml, heat to dissolve, cool, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (O. 1 mol/L) titration to the solution is green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 25.52mg of C9H13N5O4.
Last Update：2022-01-01 11:56:18
Ganciclovir - Category
Authoritative Data Verified Data
antiviral drugs.
Last Update：2022-01-01 11:56:18
Ganciclovir - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:56:18
Ganciclovir - Ganciclovir and sodium chloride injection
Authoritative Data Verified Data
This product is a sterilized aqueous solution of ganciclovir and sodium chloride. Ganciclovir-containing (C0H13N5O4) shall be 90.0% to 110.0% of label and sodium chloride (NaCl)-containing shall be 95.0% to 105.0% of label.
trait
This product is colorless and clear liquid.
identification
- take an appropriate amount of this product (about equivalent to ganciclovir 20mg), put it on a water bath to evaporate, let it cool, add hydrochloric acid lml and potassium chlorate O.lg, the residue was evaporated to dryness on a water bath, and a few drops of ammonia test solution were added to the residue to show purplish red color; A few drops of sodium hydroxide test solution were added, and the purplish red color disappeared.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the ganciclovir control solution.
- This product sodium salt identification (1) reaction and chloride identification (1) reaction (General rule 0301).
examination
- the pH value should be 7.0 to 9.0 (General 0631).
- Related substances a solution containing about 0.3mg of ganciclovir per 1 ml was prepared by diluting the product with the mobile phase, which was used as a test solution for determination according to the method for ganciclovir related substances. Except for the sodium chloride peak, if there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- take 50ml of heavy metal, evaporate to about 20ml on a water bath, let it cool, add 2ml of acetate buffer (pH 3.5) and appropriate amount of water to make 25ml, inspection according to law (General Principles 0821, Law 1), containing heavy metals must not exceed three million. The osmolality should be 270 to 310 mosmol/kg (General 0632).
- bacterial endotoxin this product, according to the law to check (General 1143), the amount of endotoxin per lml should be less than 0.50EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- ganciclovir was measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-water (5:95) as mobile phase; The detection wavelength was 252nm. The number of theoretical plates is not less than 3000 according to the ganciclovir peak.
- determination precision: take an appropriate amount of this product and quantitatively dilute it with mobile phase to prepare a solution containing 40ug of ganciclovir per 1 ml as a test solution; Take about 25mg of ganciclovir reference substance, put it in a 25ml measuring flask, add 1 ml of 0.4% sodium hydroxide solution to dissolve it, dilute it to the scale with mobile phase, shake it, take an appropriate amount with precision, and dilute it with mobile phase to make a solution containing 40ug per 1 ml, as a control solution. 20 u1 of the test solution and the reference solution were respectively injected into the liquid chromatograph, and the chromatograms were recorded. According to the external standard method to calculate the peak area, that is.
- sodium nitride precision measure 10ml of this product, add 40ml of water, 5ml of 2% dextrin solution, and 0.lg and fluorescent yellow indicator solution 5~8 drops, with silver nitrate titration solution (0.lmol/L) titration, each lm l silver nitrate titration solution (0.1 mol/L) corresponds to 5.844mg of NaCl.
category
Same as ganciclovir.
specification
- 100ml: 0.05g ganciclovir and 0.9g sodium chloride
- 100ml: ganciclovir 0.lg with sodium chloride 0.9g
- 250ml: ganciclovir 0.25g with sodium chloride 2.25g
storage
sealed storage.
Last Update：2022-01-01 11:56:19
Ganciclovir - Ganciclovir for injection
Authoritative Data Verified Data
This product is ganciclovir plus the right amount of sodium hydroxide solution, by freeze-drying of sterile products. Based on the average loading, ganciclovir (C9H13N5O4) should be 90.0%-110.0% of the standard water content.
trait
This product is a white loose block or powder; There is moisture.
identification
- take an appropriate amount of this product (about 20mg of ganciclovir), add 2ml of hydrochloric acid, put it on a water bath to evaporate, add lml of hydrochloric acid and about 30mg of potassium chlorate, put it on a water bath to evaporate dry, A few drops of ammonia test solution were added to the residue, and then several drops of sodium hydroxide test solution were added. The purple color disappeared. If there is interference, take the white precipitate under identification (3) and test again.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of this product, add water to dissolve, adjust to Neutral with dilute hydrochloric acid or ammonia test solution, that is, generate white precipitate, filter, filtrate sodium salt identification (1) reaction (General 0301).
examination
- alkalinity this product is dissolved in water and diluted to prepare a solution containing 12.5mg of ganciclovir per 1 ml, which is measured according to law (General rule 0631). The pH value should be 10.5~11.5.
- clarity of solution take this product, add water to dissolve and dilute into ganciclovir lOmg solution per 1 ml, the solution should be clear, if it is turbid, compared with No. 1 turbidity standard solution (General Principles 0902 first method), should not be more concentrated.
- Related substances the product was taken, dissolved by adding mobile phase and diluted to give a solution containing about 0.3mg of ganciclovir per 1 ml, which was used as a test solution and measured according to the method under ganciclovir related substances. If there are impurity peaks in the chromatogram of the test solution, the sum of the peak areas of each impurity shall not be greater than the area of the main peak of the control solution (1.0%).
- the moisture content of this product shall not exceed 0832 as determined by the method for determination of moisture (General rule 6.0%, first method 1).
- bacterial endotoxin this product, according to the law inspection (General 1143), per 1 mg ganciclovir containing endotoxin should be less than 0.50EU.
- sterile take this product, add 0.9% sterile sodium chloride solution to dissolve the appropriate amount, after the membrane filtration method, according to the law (General 1101), should comply with the provisions.
- others should be in accordance with the relevant provisions under injection (General rule 0l02).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-water (5:95) as mobile phase; The detection wavelength was 252mn. The number of theoretical plates is not less than 3000 according to the ganciclovir peak.
- 5 pieces of this product were measured, and the contents of each container were accurately weighed, and the contents of each container were dissolved with mobile phase, and then the whole amount was transferred to the same measuring flask and mixed well, take appropriate amount with precision and dilute quantitatively with mobile phase to make a solution containing 40ug of ganciclovir per 1 ml as a test solution. Take 25mg of ganciclovir as the control substance and place it in a 25ml measuring flask, add 0.4% sodium hydroxide solution lm l to dissolve, dilute to scale with mobile phase, shake well, take appropriate amount with precision, and quantitatively dilute with mobile phase to prepare a solution containing about 40ug per 1 ml as a reference solution. 20 u1 of the test solution and the reference solution were respectively injected into the human liquid chromatograph, and the chromatograms were recorded. According to the external standard method to calculate the peak area, that is.
category
Same as ganciclovir.
specification
(1)0.05g (2)0.15g (3)0.25g (4)0.5g
storage
light shielding, closed storage.
Last Update：2022-01-01 11:56:20
Supplier List
Featured ProductsSpot supply
Product Name: GANCICLOVIR Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Ganciclovir Request for quotation
CAS: 82410-32-0
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 82410-32-0
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Multiple SpecificationsSpot supply
Product Name: Ganciclovir Request for quotationCAS: 82410-32-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1H-purin-6(9H)-one Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: BW 759; 2'-Nor-2'-deoxyguanosine Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: C9H13N5O4 Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Ganciclovir Request for quotation
CAS: 82410-32-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 82410-32-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Ganciclovir Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: GANCICLOVIR Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Ganciclovir Request for quotation
CAS: 82410-32-0
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 82410-32-0
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Multiple SpecificationsSpot supply
Product Name: Ganciclovir Request for quotationCAS: 82410-32-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1H-purin-6(9H)-one Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: BW 759; 2'-Nor-2'-deoxyguanosine Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: C9H13N5O4 Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Ganciclovir Request for quotation
CAS: 82410-32-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 82410-32-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Ganciclovir Visit Supplier Webpage Request for quotationCAS: 82410-32-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History