HOBT
1-Hydroxybenzotriazole
CAS: 2592-95-2
Molecular Formula: C6H5N3O
HOBT - Names and Identifiers
| Name | 1-Hydroxybenzotriazole |
| Synonyms | HOBt HOBT 1-HOB 1-HYDROXYBENZOTRIAZOL N-Hydroxybenzotrizole 1-HYDROXYBENZOTRIAZOLE 1-Hydroxybenzotriazole 1-HYDROXYLBENZOTRIAZOLE 1-HYDROXY-1-H-BENZOTRIAZOLE 1-Hydroxybenzotriazole 〔HBT〕 1-HYDROXY-1,2,3-BENZOTRIAZOLE 1-hydroxybenzotriazole anhydrous |
| CAS | 2592-95-2 |
| EINECS | 219-989-7 |
| InChI | InChI=1/C6H5N3O.H3N/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H3 |
HOBT - Physico-chemical Properties
| Molecular Formula | C6H5N3O |
| Molar Mass | 135.12 |
| Density | 1 g/cm3 |
| Melting Point | 156-159°C |
| Boling Point | 149-150°C |
| Flash Point | 95°C |
| Water Solubility | 4.201g/L at 29℃ |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.009Pa at 25℃ |
| Appearance | White to white-like crystals or powders |
| Color | White to off-white crystalline powder |
| pKa | 7.39±0.58(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Stable, but possible risk of explosion if heated under confinement. Flammable. |
| Refractive Index | n20/D 1.488 |
| MDL | MFCD00005805 |
| Physical and Chemical Properties | Melting point 156-159°C white crystalline powder |
| Use | Intermediates and polypeptide protectants for the synthesis of ubenimex |
HOBT - Risk and Safety
| Risk Codes | R11 - Highly Flammable R5 - Heating may cause an explosion R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R20/21 - Harmful by inhalation and in contact with skin. R61 - May cause harm to the unborn child R2 - Risk of explosion by shock, friction, fire or other sources of ignition |
| Safety Description | S16 - Keep away from sources of ignition. S33 - Take precautionary measures against static discharges. S7/9 - S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. S15 - Keep away from heat. S36/37 - Wear suitable protective clothing and gloves. S35 - This material and its container must be disposed of in a safe way. |
| UN IDs | 1325 |
| RTECS | DM1288000 |
| HS Code | 29339980 |
| Hazard Class | 4.1 |
| Packing Group | III |
HOBT - Upstream Downstream Industry
| Raw Materials | hydrazine hydrate |
HOBT - Reference
| Reference Show more | 1. Liu Yu Tang Bin Li Song. Trametes sp. Optimization of decolorization conditions of Acid chrome blue K catalyzed by LS-10C laccase [J]. Journal of Anhui Polytechnic University, 2016, 31(004):12-16. 2. Li, Zhi-peng, et al. "Liver-targeting and pH-sensitive sulfided hyaluronic acid mixed micels for Henan therapy." International journal of nanomedicine14 (2019): 9437.https://dx.doi.org/10.2147/IJN.S214528 3. [IF = 6.953] Linglan Yang et al."Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment."Int J Biol Macromol. 2021 Jan;166:166 4. [IF=5.115] Zhi-peng Li et al."Liver-Targeting and pH-Sensitive Sulfated Hyaluronic Acid Mixed Micelles for Hepatoma Therapy."Int J Nanomed. 2019; 14: 9437-9452 |
HOBT - Reference Information
| LogP | 0.146 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | Used as an intermediate in organic synthesis Used in polypeptide synthesis. Synthesis of Ubenimex intermediates and polypeptide protectants. Used as an intermediate in organic synthesis. Using DCC as a condensing agent to inhibit racemization in peptide synthesis |
Last Update：2024-04-10 22:29:15
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Raw Materials for HOBT