Hyoscyamine
Hyoscyamine
CAS: 101-31-5
Molecular Formula: C17 H23 N O3
Hyoscyamine - Names and Identifiers
| Name | Hyoscyamine |
| Synonyms | L-(P) Hyoscyamine L-Hyoscyamine (-)-hyoscyamin HYOSCYAMINE,USP L-Hyoscyamine free base L-Hyoscyamine (Daturine) L-HYOSCYAMINE FREE BASE CRYSTALLINE 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate 8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate [3(S)-ENDO]-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER, ALPHA-(HYDROXYMETHYL)-BENZENEACETIC ACID Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo3.2.1oct-3-yl ester, (.alpha.S)- |
| CAS | 101-31-5 |
| EINECS | 202-933-0 |
| InChI | InChI=1/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16-/m1/s1 |
| InChIKey | RKUNBYITZUJHSG-FXUDXRNXSA-N |
Hyoscyamine - Physico-chemical Properties
| Molecular Formula | C17 H23 N O3 |
| Molar Mass | 289.37 |
| Density | 1.0470 (rough estimate) |
| Melting Point | 108,5°C |
| Boling Point | 431.53°C (rough estimate) |
| Specific Rotation(α) | D20 -21.0° (alc) |
| Flash Point | 213.738°C |
| Water Solubility | 3.6g/L(20 ºC) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder |
| Color | white |
| Merck | 14,4858 |
| pKa | pKa (21°) 9.7 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5200 (estimate) |
| Physical and Chemical Properties | White crystalline powder, odorless, bitter and hot taste. Easily racemic, alkaline aqueous solution. MP 108.5 ° C., specific optical rotation [α]20D-21 ° (ethanol). This product is very soluble in ethanol and dilute acid, soluble in chloroform (1:1), soluble in water (1:280), ether (1:69) and benzene (1:159). |
| In vitro study | In steady-state kinetic measurements, L-hyoscyamine increased the conversion number of TPase activity from 0.19 min-1 to 2.11 min-1. R-(+)-hyoscyamine causes [in CHO cells, Hyoscyamine prevents stimulant-induced cAMP production with an EC50 of 7.8 nM. S-(-)-hyoscyamine enhanced forskolin-stimulated ring AMP synthesis in mouse heart (atrial and ventricular) membranes by 24%. |
| In vivo study | In conscious rats, L-hyoscyamine (20 mg/kg) prolonged the cycle period of the transitional electromyographic complex (MMC) from 17.6 min to 29.0 min. |
Hyoscyamine - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | 26/28 - Very toxic by inhalation and if swallowed. |
| Safety Description | S24 - Avoid contact with skin. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | NH0875000 |
| HS Code | 29339900 |
| Hazard Class | 6.1 |
| Packing Group | I |
Hyoscyamine - Nature
Open Data Verified Data
- scopolamine appearance is brown viscous liquid, relative density 1.1~1.2, melting point 108.5 ℃; Solubility (20 ℃): soluble in ethanol, chloroform and benzene, slightly soluble in water and ether; stability: light, thermal stability, easy to acid, alkali hydrolysis.
- dosage form 25% scopolamine emulsifiable concentrate (containing scopolamine, scopolamine, and anisodamine), 25% scopolamine-aconitine aqueous solution, and scopolamine/nicotine suspension.
Last Update：2024-01-02 23:10:35
Hyoscyamine - Preparation Method
Open Data Verified Data
distributed in Solanaceae plants such as Belladonna, scoparia stram,oni-folia> Datura stram, onite, Datura, etel. As well as in plants such as scopolamine Scopolamine (Sco Pol IA Angata). Refined from natural plant extracts.
Last Update：2025-06-07 19:20:19
Hyoscyamine - Application
Open Data Verified Data
The Botanical insecticide has the effects of killing, gastric poison and repelling to many kinds of crop pests, and is mainly applied to the control of cabbage and cabbage.
Last Update：2025-08-19 16:24:40
Hyoscyamine - Safety
Open Data Verified Data
- This product is of low toxicity. If poisoning symptoms are found, it is necessary to vomit or swallow activated carbon and send it to the hospital for treatment if necessary.
- should be stored in a cool and dry place to prevent exposure to the sun.
Last Update：2022-01-01 11:18:31
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Product Name: L-Hyoscyamine Request for quotationCAS: 101-31-5
Tel: 400-968-2212
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Product Name: L-Hyoscyamine Visit Supplier Webpage Request for quotationCAS: 101-31-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: L-Hyoscyamine Visit Supplier Webpage Request for quotationCAS: 101-31-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: L-Hyoscyamine Visit Supplier Webpage Request for quotationCAS: 101-31-5
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
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