Isofagomine
Isofagomine
CAS: 169105-89-9
Molecular Formula: C6H13NO3
Isofagomine - Names and Identifiers
Isofagomine - Physico-chemical Properties
| Molecular Formula | C6H13NO3 |
| Molar Mass | 147.17 |
| Density | 1.279±0.06 g/cm3(Predicted) |
| Boling Point | 317.2±37.0 °C(Predicted) |
| Solubility | Soluble in water and ethanol. |
| Appearance | Yellow low melting point solid |
| pKa | 14.19±0.60(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| MDL | MFCD04039581 |
| In vivo study | Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates. |
Isofagomine - Reference Information
| Biological activity | Afegostat is a pharmacological partner, high affinity and specific and reversible binding Acid β-glucosidase (GCase) in the endoplasmic reticulum (ER). |
| target | GCase |
| in vivo research | Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates. |
Last Update：2024-04-09 20:52:54
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