KM65
benzonatate
CAS: 104-31-4
Molecular Formula: C30H53NO11
KM65 - Names and Identifiers
KM65 - Physico-chemical Properties
| Molecular Formula | C30H53NO11 |
| Molar Mass | 603.74 |
| Density | 1.096±0.06 g/cm3(Predicted) |
| Boling Point | 649.0±55.0 °C(Predicted) |
| Flash Point | 346.3°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 9.98E-17mmHg at 25°C |
| Appearance | Oil |
| Color | Light Yellow to Light Brown |
| pKa | 2.20±0.39(Predicted) |
| Storage Condition | Refrigerator, under inert atmosphere |
| Refractive Index | 1.495 |
| Physical and Chemical Properties | Light yellow viscous liquid. Soluble in cold water, but insoluble in hot water. Soluble in most organic solvents for cough medicine, antitussive effect intensity slightly lower than codeine, but does not inhibit breathing, bronchial asthma patients after medication, the reaction can deepen breathing, minute ventilation increased. |
| Use | Commonly used in acute bronchitis, bronchial asthma, Pneumonia, lung cancer caused by the stimulation of Dry Cough, such as cough. The preparation was sugar-coated pills. |
KM65 - Risk and Safety
| Toxicity | LD50 oral in mouse: 400mg/kg |
KM65 - Upstream Downstream Industry
| Raw Materials | 4-Nitrobenzoic acid |
KM65 - Reference Information
| introduction | benzozonate is a peripheral non-addictive antitussive. It has a strong local anesthetic effect on respiratory tract receptors, has a significant inhibitory effect on lung stretch receptors and sensory nerve tips, inhibits lung vagus nerve reflex, reduces the afferent of cough impulse, and has a certain inhibitory effect on the cough center. |
| effect | antitussive effect is slightly weaker than codeine phosphate, but does not affect the respiratory center, and antitussive drug can increase lung ventilation. It is used for irritating dry cough caused by acute bronchitis, lung cancer, pneumonia, etc., and to prevent cough during bronchoscopy, laryngoscopy, and bronchography. |
| use | antitussive. |
| production method | ethyl p-aminobenzoate is first condensed with bromobutane at 140-150 ℃, and then condensed with polyethylene glycol methyl ether at 105 ℃ to obtain cough. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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Raw Materials for KM65