KPT-8602
KPT-8602
CAS: 1642300-52-4
Molecular Formula: C17H10F6N6O
KPT-8602 - Names and Identifiers
KPT-8602 - Physico-chemical Properties
| Molecular Formula | C17H10F6N6O |
| Molar Mass | 428.3 |
| Density | 1.57±0.1 g/cm3(Predicted) |
| Boling Point | 574.4±60.0 °C(Predicted) |
| Solubility | DMSO: 4.72 mg/mL |
| pKa | 13.06±0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In cell viability assays, KPT-8602 were potent inhibitors of AML cells. It inhibits XPO1/cargo interaction and nuclear export, induces apoptosis in primary CLL cells and significantly inhibits proliferation of diffuse large B- cell lymphoma cell lines. |
| In vivo study | KPT-8602 has Oral activity, and selinexor has similar pharmacokinetic activity, but the blood brain barrier penetration is significantly reduced. Toxicity tests in rats and monkeys showed that KPT-8602 was safe and well tolerated, possibly due to its inability to penetrate the blood-brain barrier into the central nervous system, anorexia, restlessness, there was a decrease in the symptoms of weight loss. KPT-8602 had better anti-leukemic activity and better tolerability in the AML PDX model. In the AML-CN model, almost complete elimination was achieved for human AML cells. KPT-8602 has little toxicity to normal hematopoietic stem cells and progenitor cells. After repeated dosing, KPT-8602 did not accumulate in plasma and prolonged the survival of the human leukemia xenograft model. |
KPT-8602 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.335 ml | 11.674 ml | 23.349 ml |
| 5 mM | 0.467 ml | 2.335 ml | 4.67 ml |
| 10 mM | 0.233 ml | 1.167 ml | 2.335 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.467 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Featured ProductsSpot supply
Product Name: Eltanexor Visit Supplier Webpage Request for quotationCAS: 1642300-52-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: KPT-8602 Request for quotationCAS: 1642300-52-4
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: KPT-8602 Request for quotationCAS: 1642300-52-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: KPT-8602 Visit Supplier Webpage Request for quotationCAS: 1642300-52-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: KPT-8602 Visit Supplier Webpage Request for quotationCAS: 1642300-52-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: KPT-8602 Visit Supplier Webpage Request for quotation
CAS: 1642300-52-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1642300-52-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Eltanexor Visit Supplier Webpage Request for quotationCAS: 1642300-52-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: KPT-8602 Request for quotationCAS: 1642300-52-4
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: KPT-8602 Request for quotationCAS: 1642300-52-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: KPT-8602 Visit Supplier Webpage Request for quotationCAS: 1642300-52-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: KPT-8602 Visit Supplier Webpage Request for quotationCAS: 1642300-52-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: KPT-8602 Visit Supplier Webpage Request for quotation
CAS: 1642300-52-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1642300-52-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History