Molecular Formula | C22H19N3O5 |
Molar Mass | 405.4 |
Density | 1.401±0.06 g/cm3(Predicted) |
Boling Point | 510.1±50.0 °C(Predicted) |
Solubility | DMSO : ≥ 35 mg/mL (86.33 mM) |
Appearance | powder |
Color | white to beige |
pKa | 11.60±0.70(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
Use | KS176 is a selective and highly active breast cancer drug resistance protein multidrug transport channel (BCRP) inhibitor (IC50 values in Pheo A and Hoechst tests are 0.59 and 1.39 μM respectively). No inhibitory activity on P-gp and MRP1. |
Target | BKCa-channel; BCRP(Pheo A) |
WGK Germany | 3 |
Reference Show more | 1. Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem. 2010 Sep 3;5(9):1498-505. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.467 ml | 12.333 ml | 24.667 ml |
5 mM | 0.493 ml | 2.467 ml | 4.933 ml |
10 mM | 0.247 ml | 1.233 ml | 2.467 ml |
5 mM | 0.049 ml | 0.247 ml | 0.493 ml |
biological activity | KS176 (compound 9) is an effective and selective inhibitor of breast cancer resistance protein (BCRP, ABCG2) multidrug transporter. IC50 values in Hoechst 33342 analysis and Pheo A analysis are 1.39 μM and 0.59 μM respectively. |
target | TargetValue BCRP (in Pheo A say) 0.59 μM BCRP (in Hoechst 33342 say) 1.39 μM |
Target | Value |
BCRP (in Pheo A assay) | 0.59 μM |
BCRP (in Hoechst 33342 assay) | 1.39 μM |