Kojic
Kojic acid
CAS: 501-30-4
Molecular Formula: C6H6O4
Kojic - Names and Identifiers
Kojic - Physico-chemical Properties
| Molecular Formula | C6H6O4 |
| Molar Mass | 142.11 |
| Density | 1.1712 (rough estimate) |
| Melting Point | 152-155 °C (lit.) |
| Boling Point | 179.65°C (rough estimate) |
| Water Solubility | SOLUBLE |
| Solubility | A melanin-specific inhibitor, soluble in water, easily soluble in acetone and ethanol, slightly soluble in ether, ethyl acetate, chloroform and pyridine; insoluble in benzene. |
| Appearance | Yellow brown powder |
| Color | White to beige-brown |
| Maximum wavelength(λmax) | ['269nm(CHCl3)(lit.)'] |
| Merck | 14,5317 |
| BRN | 120895 |
| pKa | 7.9(at 25℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.4434 (estimate) |
| MDL | MFCD00006580 |
| Physical and Chemical Properties | dissolved in water, alcohol, acetone, slightly soluble in ether, ethyl acetate, chloroform and pyridine, insoluble in benzene. melting point 151-156°C |
| Use | For cosmetics, food additives, pharmaceutical, etc |
Kojic - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R40 - Limited evidence of a carcinogenic effect R68 - Possible risk of irreversible effects |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | UQ0875000 |
| HS Code | 29329995 |
Kojic - Upstream Downstream Industry
| Raw Materials | Starch potato |
Kojic - Reference
| Reference Show more | 1. Liu Rong, Sun Weidong, Li Jun committee. Optimization of fermentation medium for kojic acid production from sucrose by Aspergillus oryzae [J]. Light Industry Science and Technology, 2016, 26 (10):5-7. 2. Liu Rong, Sun Weidong, Li Jun committee, etc. Study on fermentation conditions of kojic acid production by Aspergillus oryzae [J]. Guangxi Agricultural Journal, 2016, 06(v.18;No.73):31-35. 3. Tao, Yi, et al. "Magnetic solid-phase extraction coupled with HPLC-Q-TOF-MS for rapid analysis of tyrosinase bins from San-Bai decation by Box-Behnken statistical design." RSC advances 6.111 (2016): 109730-109741.https:// doi.org/10.1039/C6RA22045B 4. [IF = 3.361] Yi Tao et al."Magnetic solid-phase extraction coupled with HPLC-Q-TOF-MS for rapid analysis of tyrosinase binders from San-Bai decoction by Box-Behnken statistical design."Rsc Adv. 2016 Nov;6(111):109730-109741 5. [IF=4.411] Huidan Huang et al."Palladium(II)-Catalyzed Efficient Synthesis of Wedelolactone and Evaluation as Potential Tyrosinase Inhibitor."Molecules. 2019 Jan;24(22):4130 6. [IF=4.329] Lin Song et al."Synthesis, Antimicrobial Moisture Absorption and Retention Activities of Kojic Acid-Grafted Konjac Glucomannan Oligosaccharides."Polymers-Basel. 2019 Dec;11(12):1979 7. [IF=4.952] Yulong Wei et al."Characterization of blueberry (Vaccinium corymbosum L.) catechol oxidases III binding mechanism in response to selected substrates and inhibitors."Lwt Food Sci Technol. 2022 Mar;158:113142 8. [IF=2.281] Zihui Ma et al."Studies on the biosynthetic pathways of melanin in Auricularia auricula."JOURNAL OF BASIC MICROBIOLOGY |
Kojic - Introduction
It is a melanin-specific inhibitor. After entering the skin cells, it can complex with the copper ions in the cells, change the three-dimensional structure of tyrosinase, prevent the activation of tyrosinase, and inhibit the formation of melanin. It is present in Aspergillus (Aspergillus) medium for wine making. It can be produced by aerobic fermentation of Aspergillus oryzae (Aspergillus oryzae). Used as a reagent for quantitative analysis of ferric iron. Metal chelating agent. Verification of copper and hexavalent uranium. Photometric determination of high iron ions.
Last Update：2022-10-16 17:25:35
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Raw Materials for Kojic