L-101
Biuret
CAS: 108-19-0
Molecular Formula: C2H5N3O2
L-101 - Names and Identifiers
| Name | Biuret |
| Synonyms | L-101 Biuret Isobiuret Carbamylurea Dicarbamylamine allophanimidicacid (aminocarbonyl)-ure Allophamicacidamide Allophanimidic acid Biuret Allophanamide dicarbonimidic diamide Dicarbonimidic diamide 2-formylhydrazinecarboxamide |
| CAS | 108-19-0 |
| EINECS | 203-559-0 |
| InChI | InChI=1/C2H5N3O2/c3-2(7)5-4-1-6/h1H,(H,4,6)(H3,3,5,7) |
L-101 - Physico-chemical Properties
| Molecular Formula | C2H5N3O2 |
| Molar Mass | 103.08 |
| Density | 1.01g/mLat 20°C |
| Melting Point | 185-190 °C (dec.) (lit.) |
| Boling Point | 100 °C |
| Water Solubility | 2 g/100 mL (25 ºC) |
| Solubility | Easily soluble in ethanol, slightly soluble in ether. |
| Appearance | White crystal |
| Color | White |
| Odor | Odorless |
| Merck | 14,1309 |
| BRN | 1703510 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. Hygroscopic. |
| Sensitive | Hygroscopic |
| Refractive Index | 1.4264 (estimate) |
| MDL | MFCD00007946 |
| Physical and Chemical Properties | Long white crystals. Melting point 190 ° C (decomposition), the relative density of 1.467(-5/4 deg C). The Crystal in water contains 4 molecules of crystal water and loses water at about 110 °c. Soluble in alcohol, very slightly soluble in ether. |
| Use | Used as pharmaceutical intermediates, growth hormone, foaming agent, paint |
L-101 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29241990 |
L-101 - Reference
| Reference Show more | 1. Hou yinchen, Lv xing, Huang Jihong, et al. Optimization of fermentation process conditions for defatted wheat germ [J]. Food Industry, 2019, v.40;No.278(11):84-87. 2. Yu Yahui, Fang Ting. Analysis of seafood flavor base prepared from abalone cooking solution and its flavor components [J]. Chinese condiment, 2020, v.45;No.491(01):43-48. |
L-101 - Nature
Open Data Verified Data
Biuret is a non-protein nitride, odorless, extremely toxic, white crystalline or crystalline powder, not deliquescent. Slightly soluble in ether.
Last Update：2024-01-02 23:10:35
L-101 - Preparation Method
Open Data Verified Data
Industrial urea co-production method, with the middle of the urine as raw material, through high temperature heat shrinkage, separation, drying to get the finished product. In the laboratory, urea and disodium hydrogen phosphate can be dissolved in water, reacted at 150~160 ℃ for 2H, and then poured into cold water overnight to separate out crystals, I .e., biuret.
Last Update：2025-06-10 22:55:16
L-101 - Introduction
No smell. It's hygroscopic. Crystallizers in water contain 4 molecules of crystal water. Water loss at about 110 ℃, decomposition at 193 ℃, melamine at higher temperature. The solubility in water increases with the increase of temperature (g/100g):2 · 01 at 25 ℃, 7 · 0 at 50 ℃, 20 at 75 ℃, and 53 · 5 at 105 ℃. The aqueous solution is light purple when it reacts with copper sulfate and sodium hydroxide.
Last Update：2022-10-16 17:11:55
L-101 - Application
Open Data Verified Data
as a non-protein nitrogen source added to the feed, the protein is synthesized by microorganisms in the rumen of animals to meet the needs of animals for protein, safer than urea; It is an excellent animal feed additive.
Last Update：2025-08-19 16:24:40
L-101 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | biuret is the product generated by deamination and condensation reaction when the temperature is higher than the melting point of urea (150-170 ℃) in the urea production process. The chemical formula is NH2CONHCONH2. The reaction formula is as follows-NH2CONH2-(heating)->HNCO + NH3; HNCO + NH2CONH2 → NH2CONHCONH2, crystalline urea will also generate this substance in the granulation process, which is toxic to plants, so it is required that the biuret content in urea should not exceed 1%. The content of biuret in urea used for topdressing outside the root should not exceed 0.5%. |
| diuret reaction | protein produces purple red in basic copper sulfate solution, which is because basic copper sulfate and peptide bonds (-NHCO-) in protein form Because of the complex. Regarding the structure of the purplish red product, there are generally different opinions. Schiff once isolated the compound (Ⅰ)(purplish red crystal) in the following reaction from the simplest urea reaction solution. The related chemical reaction equation is as follows: Some people use spectrophotometry to study, and believe that the colored substances produced by the urea reaction are mainly formed by tripeptides and tetrapeptides, the complex formed by the coordination of copper and trititanium is purple, and the complex formed by the coordination of copper and tetrapeptide is red. This reaction is not very sensitive, because substances containing one peptide bond and one other group also undergo diuret reaction; some substances without peptide bonds (such as histidine) can also undergo this reaction. Therefore, its application in research work is limited. |
| use | used in ruminant feed, it is the same as urea as a feed additive, but it is safer than urea. Used as pharmaceutical intermediate, growth hormone, foaming agent, lacquer used in analytical chemistry. |
| production method | urea, water and disodium hydrogen phosphate are mixed evenly and dissolved by heating. Raise the temperature to 150-160 ℃ and keep the temperature for 2 hours. After the reaction, the reactants are poured into water, left overnight, filtered out and crystallized into crude, and recrystallized with dilute ammonia to obtain the finished biuret. In urea production, intermediate urine is used as raw material, and the finished product is obtained by heat shrinkage, separation and drying at high temperature. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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