Lafutidine
Lafutidine
CAS: 118288-08-7
Molecular Formula: C22H29N3O4S
Lafutidine - Names and Identifiers
| Name | Lafutidine |
| Synonyms | Lafutidine 118288-08-07 Adefovir Dipivioxil LAFUTIDINE(SUBJECTTOPATENTFREE) n-(4-(4-piperidinylmethyl)pyridyl-2-oxy)butenyl-2-(furfurylsulfinyl)acetamide (Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1- (Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl) 2-((Furan-2-ylMethyl)sulfinyl)-N-(4-((4-(piperidin-1-ylMethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetaMide (Z)-2-((Furan-2-ylMethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylMethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetaMide 2-[(furan-2-ylmethyl)sulfinyl]-N-[(2Z)-4-{[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy}but-2-en-1-yl]acetamide |
| CAS | 118288-08-7 |
| EINECS | 601-513-8 |
| InChI | InChI=1/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2- |
Lafutidine - Physico-chemical Properties
| Molecular Formula | C22H29N3O4S |
| Molar Mass | 431.55 |
| Density | 1.252±0.06 g/cm3(Predicted) |
| Melting Point | 92.7-94.9° |
| Boling Point | 704.2±60.0 °C(Predicted) |
| Flash Point | 379.7°C |
| Water Solubility | Insoluble in water |
| Solubility | DMSO 86 mg/mL Water <1 mg/mL Ethanol 13 mg/mL |
| Vapor Presure | 1.12E-19mmHg at 25°C |
| Appearance | White to beige powder |
| Color | White to Orange to Green |
| pKa | 13.13±0.46(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.598 |
| MDL | MFCD00867520 |
| Use | Drugs for digestive system |
Lafutidine - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29349990 |
Lafutidine - Nature
Open Data Verified Data
melting point 92.7-94.9 °c. Soluble in DMF, acetic acid, soluble in methanol, almost insoluble in water.
Last Update：2025-06-10 22:55:16
Lafutidine - Preparation Method
Open Data Verified Data
The sodium hydride was suspended in Tetrahydrofuran, and a tetrahydrofuran solution of (Z) -4-tetrahydropyranoxy-2-butenol was added dropwise at room temperature, in turn add 2 chlorine 4 piperidyl methyl pyridine and dimethyl formamide, reaction is completed, after processing (Z) -4-piperidinylmethyl -2-(4-tetrahydropyridyloxy-2-butene-oxy) pyridine. The compound is dissolved in methanol, under cooling in an ice bath, P-toluenesulfonic acid monohydrate is added, and the reaction is stirred to obtain (z) -4-[4-(piperidinyl methyl) pyridin-2-oxy]-2-butenol. The compound and triethylamine were dissolved in toluene, and a toluene solution of methanesulfonyl chloride was added dropwise under cooling in an ice bath, stirred, and treated to give a solution. In 2 a toluene solution of furan methyl sulfinyl acetamide is added potassium tert-butoxide, drop plus surface obtained solution reaction, after treatment to obtain lafutidine.
Last Update：2025-06-10 22:55:16
Lafutidine - Introduction
Lafutidine is a newly developed histamine H(2) receptor antagonist that inhibits gastric acid secretion.
Last Update：2022-10-16 17:12:28
Lafutidine - Application
Open Data Verified Data
lafutidine was jointly developed by Fuji (Fujire-bio) and Taiho companies in Japan and was launched in Japan in April 2000. It is a potent, long-acting second-generation histamine H2 receptor antagonist with a unique gastric protective effect. It can reduce the basal secretion of gastric acid and inhibit the gastric acid secretion stimulated by histamine, gastrin and urethane. Compared with cimetidine, famotidine and other similar drugs, the blocking effect on H2 receptor is more effective and lasting, so it has the advantage of anti-gastric acid secretion. Mainly for the treatment of gastric ulcer, duodenal ulcer and acute or chronic gastritis.
Last Update：2025-08-19 16:24:40
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Mobile: 18021002903
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Product Name: Lafutidine Visit Supplier Webpage Request for quotationCAS: 118288-08-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Lafutidine Request for quotationCAS: 118288-08-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Lafutidine Visit Supplier Webpage Request for quotationCAS: 118288-08-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: FRG-8813 Visit Supplier Webpage Request for quotationCAS: 118288-08-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Lafutidine Visit Supplier Webpage Request for quotationCAS: 118288-08-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Lafutidine Visit Supplier Webpage Request for quotation
CAS: 118288-08-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 118288-08-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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