Lexacalcitol
Lexacalcitol
CAS: 131875-08-6
Molecular Formula: C29 H48 O4
Lexacalcitol - Names and Identifiers
Lexacalcitol - Physico-chemical Properties
| Molecular Formula | C29 H48 O4 |
| Molar Mass | 460.69 |
| Density | 1.07±0.1 g/cm3(Predicted) |
| Boling Point | 600.3±55.0 °C(Predicted) |
| pKa | 14.43±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Lexacalcitol inhibits cell proliferation by 50% at 10 -12 M (14,000 times more active than la,25(OH) 2 D 3 ) in human histiocytic lymphoma cell line U 937. Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10 -16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10 -15 M. |
| In vivo study | Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients. Animal Model: Male and female spontaneously diabetic NOD mice Dosage: 0.5 mg/kg/2 days Administration: Intraperitoneal injection Result: Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice. |
Lexacalcitol - Introduction
The activity of Lexacalcitol (KH1060) is 100 times that of 1alpha,25-(OH)2D3.
Last Update：2022-10-16 17:42:01
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