Linagliptin
Linagliptin
CAS: 668270-12-0
Molecular Formula: C25H28N8O2
Linagliptin - Names and Identifiers
Linagliptin - Physico-chemical Properties
| Molecular Formula | C25H28N8O2 |
| Molar Mass | 472.54 |
| Density | 1.39 |
| Melting Point | 202 ºC |
| Boling Point | 661.2±65.0 °C(Predicted) |
| Flash Point | 353.675°C |
| Solubility | Soluble in DMSO (17 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (1 mg/ml |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | White to Orange |
| pKa | 10.01±0.20(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.717 |
| Use | A highly potent, selective CD26 (DPP-4) inhibitor. |
| In vitro study | In vitro, Linagliptin exhibited potent inhibition of DPP-4 with low affinity for the hERG channel and M1 receptor (IC50 295 nM). In vitro, Linagliptin acts as a competitive inhibitor with K I of 1 nM, selectivity to DPP-4 versus DPP-8,DPP-9, aminopeptidases N and P, prolyl oligopeptidase, trypsin, plasmin, and thrombin, were 10,000-fold higher than fibroblast activation protein, 90-fold higher. |
| In vivo study | In male Wistar rats, Beagle dogs, and rhesus monkeys, Linagliptin showed potent, durable, and potent inhibitory activity against DPP-4, administered orally at a dose of 1 mg/kg, more than 70% inhibition can be achieved for all species. Oral administration of Linagliptin to db/db mice 45 minutes before the oral glucose tolerance test dose-dependently reduced blood glucose excursion from 0.1 mg/kg (15% inhibition) to 1 mg/kg (66% inhibition). By inhibiting DPP-4 activity, Linagliptin reduces the expression of proinflammatory markers oxygenase-2 and macrophage inflammatory protein -2, and enhanced the formation of myofibroblasts during wound healing in ob/ob mice. |
Linagliptin - Risk and Safety
| HS Code | 29335990 |
Linagliptin - Reference
| Reference Show more | 1. [IF=4.24] Mingxia Wu et al."Inhibitory effects of acorn (Quercus variabilis Blume) kernel-derived polyphenols on the activities of α-amylase, α-glucosidase, and dipeptidyl peptidase IV."Food Biosci. 2021 Oct;43:101224 |
Linagliptin - Introduction
Linagliptin is a highly effective, selective DPP-4 inhibitor with an IC50 of 1 nM.
Last Update：2022-10-16 17:27:49
Supplier List
Featured ProductsSpot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Linagliptin Request for quotationCAS: 668270-12-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: Linagliptin Request for quotation
CAS: 668270-12-0
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327
Send QQ message
CAS: 668270-12-0
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327
Featured ProductsSpot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Linagliptin Request for quotationCAS: 668270-12-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: Linagliptin Visit Supplier Webpage Request for quotationCAS: 668270-12-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: Linagliptin Request for quotation
CAS: 668270-12-0
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327Send QQ message
CAS: 668270-12-0
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327
View History