ML228
ML228
CAS: 1357171-62-0
Molecular Formula: C27H21N5
ML228 - Names and Identifiers
ML228 - Physico-chemical Properties
| Molecular Formula | C27H21N5 |
| Molar Mass | 415.49 |
| Density | 1.228±0.06 g/cm3(Predicted) |
| Boling Point | 686.0±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 35 mg/mL |
| Appearance | Solid |
| Color | Pale Yellow to Light Yellow |
| pKa | 2.03±0.63(Predicted) |
| Storage Condition | -20°C, Inert atmosphere |
| In vitro study | ML228 (CID-46742353) represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications. |
| In vivo study | ML228 (injection; 1 µg/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduce SCI secondary injury and promote the recovery of neurological function. Animal Model: SD rat Dosage: 1 µg/kg Administration: injection; 7 days Result: Alleviated SCI of the central nervous system and relieve associated symptoms. |
ML228 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.407 ml | 12.034 ml | 24.068 ml |
| 5 mM | 0.481 ml | 2.407 ml | 4.814 ml |
| 10 mM | 0.241 ml | 1.203 ml | 2.407 ml |
| 5 mM | 0.048 ml | 0.241 ml | 0.481 ml |
Last Update：2024-01-02 23:10:35
ML228 - Reference Information
| biological activity | ML228 (CID-46742353) is an effective HIF signal pathway activator with EC50 of 1 μM. ML228 activates HIF as well as downstream EGFR. |
| target | EC50: 1 μM (HIF) |
| in vitro study | ML228 (CID-46742353) represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications. |
| in vivo study | ML228 (injection; 1 µg/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduce SCI secondary injury and promote the recovery of neurological function. Animal Model: SD Rat Dosage: 1 µg/kg Administration: injection; 7 days Result: Alleviated SCI of the central nervous system and relieve associated symptoms. |
| Animal Model: | SD rat |
| Dosage: | 1 µg/kg |
| Administration: | injection; 7 days |
| Result: | Alleviated SCI of the central nervous system and relieve associated symptoms. |
Last Update：2024-04-09 21:11:58
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Product Name: ML228 Visit Supplier Webpage Request for quotationCAS: 1357171-62-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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Product Name: ML228 Request for quotationCAS: 1357171-62-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
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Product Name: ML228 Visit Supplier Webpage Request for quotationCAS: 1357171-62-0
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: CID-46742353 Visit Supplier Webpage Request for quotationCAS: 1357171-62-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: ML228 Visit Supplier Webpage Request for quotation
CAS: 1357171-62-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1357171-62-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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