MLN2480
MLN2480
CAS: 1096708-71-2
Molecular Formula: C17H12Cl2F3N7O2S
MLN2480 - Names and Identifiers
MLN2480 - Physico-chemical Properties
| Molecular Formula | C17H12Cl2F3N7O2S |
| Molar Mass | 506.29 |
| Density | 1.640 |
| Melting Point | 197-199oC |
| Boling Point | 585.3±50.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White |
| pKa | 10.07±0.46(Predicted) |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
| In vitro study | MLN2480 inhibits the MAPK signaling pathway in clinical cancer models carrying BRAF and some RAS mutations. MLN2480 activates phosphorylated MEK at low concentrations, but inhibits this activity at high concentrations. The inhibitory effect of MLN2480 was all different in different models and Gene contexts. In an in vitro experiment, MLN2480 and TAK-733(MEK allosteric inhibitor) were used in combination in a cell proliferation assay, and the results demonstrate that these two small molecule compounds have synergistic activity. In addition, Western blot analysis demonstrated that MLN2480 inhibited negative feedback MEK activation due to TAK-733 treatment, thereby inhibiting the MAPK signaling pathway more effectively and consistently. The inhibitory effect of MLN2480 on PARK was weak. |
| In vivo study | MLN2480 has antitumor activity in xenograft models of melanoma, colon cancer, lung cancer, and pancreatic cancer. MLN2480(37.5 mg/kg) was well tolerated in a tumor xenograft model, MLN-2480(12.5 mg) versus TAK-733 (1 mg/kg). The combined use of is very effective in a SK-MEL-30 xenograft model, but the effect of its monotherapy is extremely weak. |
MLN2480 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.975 ml | 9.876 ml | 19.752 ml |
| 5 mM | 0.395 ml | 1.975 ml | 3.95 ml |
| 10 mM | 0.198 ml | 0.988 ml | 1.975 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.395 ml |
Last Update：2024-01-02 23:10:35
MLN2480 - Reference Information
| biological activity | MLN2480 (BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101) is an oral Raf kinase inhibitor. |
| target | TargetValue Raf |
| Target | Value |
| in vitro study | MLN2480 inhibit MAPK signaling pathway in clinical cancer models carrying BRAF and some RAS mutations. MLN2480 activated phosphorylated MEK at low concentrations, but inhibited this activity at high concentrations. The inhibitory effect of MLN2480 is also different under different models and gene backgrounds. In vitro experiments, MLN2480 and TAK-733(MEK allosteric inhibitor) were used in combination in cell proliferation detection. The results proved that these two small molecule compounds have synergistic activity. In addition, Western blot analysis proves that MLN2480 inhibits negative feedback MEK activation caused by TAK-733 processing, thus suppressing MAPK signal pathway more effectively and consistently. MLN2480 has a weaker inhibitory effect on PARK. |
| in vivo study | MLN2480 has anti-tumor activity in transplanted tumor models of melanoma, colon cancer, lung cancer and pancreatic cancer. MLN2480(37.5 mg/kg) is well tolerated in tumor xenograft models. The combination of MLN-2480(12.5 mg) and TAK-733 (1 mg/kg) is very effective in SK-MEL-30 transplanted tumor models, but its monotherapy is extremely weak. |
Last Update：2024-04-09 21:54:55
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CAS: 1096708-71-2
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CAS: 1096708-71-2
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Email: 3008007409@qq.com
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Product Name: MLN2480 Request for quotationCAS: 1096708-71-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: MLN2480 Visit Supplier Webpage Request for quotationCAS: 1096708-71-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: MLN2480 Visit Supplier Webpage Request for quotationCAS: 1096708-71-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: TAK-580; MLN 2480; BIIB-024 Visit Supplier Webpage Request for quotationCAS: 1096708-71-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: MLN2480 Visit Supplier Webpage Request for quotation
CAS: 1096708-71-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1096708-71-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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