MT-DADMe-ImmA
MT-DADMe-ImmA
CAS: 653592-04-2
Molecular Formula: C13H19N5OS
MT-DADMe-ImmA - Names and Identifiers
MT-DADMe-ImmA - Physico-chemical Properties
| Molecular Formula | C13H19N5OS |
| Molar Mass | 293.39 |
| Density | 1.412±0.06 g/cm3(Predicted) |
| Melting Point | 108-110 °C |
| Boling Point | 566.1±50.0 °C(Predicted) |
| Solubility | DMSO |
| pKa | 14.13±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibit MTAP, increase cellular MTA concentrations, decrease polyamines, and induce apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. The same treatment does not induce apoptosis in normal human fibroblast cell lines (CRL2522 and GM02037) or in MCF7, a breast cancer cell line with an MTAP gene deletion. MT-DADMe-ImmA alone does not induce apoptosis in any cell line, implicating MTA as the active agent. |
| In vivo study | The t 1/2 for onset of inhibition is 50 min with complete inhibition by 250 min. MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA. |
MT-DADMe-ImmA - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.408 ml | 17.042 ml | 34.085 ml |
| 5 mM | 0.682 ml | 3.408 ml | 6.817 ml |
| 10 mM | 0.341 ml | 1.704 ml | 3.408 ml |
| 5 mM | 0.068 ml | 0.341 ml | 0.682 ml |
Last Update：2024-01-02 23:10:35
MT-DADMe-ImmA - Reference Information
| biological activity | MT-DADMe-ImmA is an inhibitor of human 5 '-methylthioadenosine phosphorylase (MTAP) with a Ki value of 90 pM. |
| Target | Ki: 90 pM (MTAP) |
Last Update：2024-04-10 22:30:50
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