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Macitentan
CAS: 441798-33-0
Molecular Formula: C19H20Br2N6O4S
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Macitentan
Macitentan -
Names and Identifiers
Name
Macitentan
Synonyms
Macitentan
ACT-064992
ACT 064992
macitentan
5-(4-BROMOPHENYL)-6-[2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY]-N-(PROPYLSULFAMOYL)PYRIMIDIN-4-AMINE
N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)-oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfami
N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide
CAS
441798-33-0
EINECS
1308068-626-2
Macitentan -
Physico-chemical Properties
Molecular Formula
C19H20Br2N6O4S
Molar Mass
588.27
Density
1.675
Boling Point
692.4±65.0 °C(Predicted)
Solubility
DMSO 100 mg/mL (169.98 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM)
pKa
4.99±0.50(Predicted)
Storage Condition
-20℃
Macitentan -
Introduction
Macitentan is an orally effective, non-peptide, ETA/ETB (endothelin) receptor dual antagonist with an IC50 of 0.5 nM/391 nM.
Last Update:2022-10-16 17:25:15
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