Metaraminol

Name	metaraminol
Synonyms	Icoral B Pressorol Pressonex HSDB 2716 CCRIS 8465 Metaradrine metaraminol L-Metaraminol Metaraminolum 1-Metaraminol UNII-818U2PZ2EH Hydroxynorephedrine m-Hydroxypropadrine m-Hydroxynorephedrine Metaraminolum [Latin] m-Hydroxy norephedrine (-)-Erythro-metaraminol Metaraminol (free base) Metaraminolum [INN-Latin] m-Hydroxyphenylpropanolamine Norephedrine, m-hydroxy- (6CI) 3-Hydroxyphenylisopropanolamine -(m-hydroxyphenyl)-2-amino-1-propanol 1-(m-Hydroxyphenyl)-2-amino-1-propanol 2-Amino-1-(m-hydroxyphenyl)-1-propanol alpha-(m-Hydroxyphenyl)-beta-aminopropanol alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol alpha-(1-Aminoethyl)-3-hydroxybenzenemethanol m-Hydroxy-alpha-(1-aminoethyl)-benzyl alcohol 1-alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol (-)-(1R,2S)-1-(m-Hydroxyphenyl)-2-amino-1-propanol Benzyl alcohol, alpha-(1-aminoethyl)-m-hydroxy-, (-)- Benzyl alcohol, a-(1-aminoethyl)-m-hydroxy-, (-)- (8CI) Benzenemethanol, a-(1-aminoethyl)-3-hydroxy-, [R-(R,S)]- Benzenemethanol, alpha-(1-aminoethyl)-3-hydroxy-, (R-(R,S))- Benzenemethanol, a-[(1S)-1-aminoethyl]-3-hydroxy-, (aR)- (9CI) Benzenemethanol, alpha-(1-aminoethyl)-3-hydroxy-, (R-(R,S))- ( 9CI)
CAS	54-49-9
InChI	InChI=1/C9H13NO2/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6,9,11-12H,10H2,1H3/t6-,9-/m0/s1

Molecular Formula	C9H13NO2
Molar Mass	167.21
Density	1.1222 (rough estimate)
Melting Point	107.5°C
Boling Point	295.79°C (rough estimate)
pKa	pKa 8.6 (Uncertain)
Refractive Index	1.4760 (estimate)
Physical and Chemical Properties	The tartaric acid salt of the product is a white crystalline powder. Melting point 176-177 °c. Easily soluble in water, the pH of 1% aqueous solution is about 3.5. Slightly soluble in ethanol, insoluble in chloroform, ether. Almost odorless and bitter.
Use	2-adrenergic receptor agonist, suitable for all kinds of Shock and low blood pressure during surgery

Overview	M-hydroxylamine mainly acts on α receptor, but weakly on β1 receptor; part of the effect is by promoting the release of norepinephrine from sympathetic nerve endings. It is suitable for the treatment of early Shock, and the prevention and treatment of acute hypotension during spinal anesthesia. It can also be used for adjuvant symptomatic treatment of hypotension due to bleeding, drug allergy, surgical complications and brain trauma or brain tumor with Shock, and also for the treatment of hypotension due to cardiogenic Shock or sepsis.
Use	is an adrenergic mimetic drug, used for acute hypotension, and is one of the commonly used drugs for rescuing patients.
production method	M-hydroxybenzaldehyde (see 21680) is prepared by enzymatic addition, condensation and catalytic hydrogenation to obtain m-hydroxylamine. The M-hydroxylamine ethanol solution was added with tartaric acid to form a salt, and the precipitated crude product was recrystallized with anhydrous and no alcohol to obtain m-hydroxylamine bitartrate.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-10 22:29:15