N-Carbobenzyloxyglycine
N-Carbobenzyloxyglycine
CAS: 1138-80-3
Molecular Formula: C10H11NO4
N-Carbobenzyloxyglycine - Names and Identifiers
| Name | N-Carbobenzyloxyglycine |
| Synonyms | z-gly N-Cbz-Gly-OH N-Carbobenzyloxyglycine N-cbz-glycine crystalline N-Benzyloxycarbonylglycine Glycine, N-(phenylmethoxy)carbonyl- N-(Benzyloxycarbonyl)glycine~Z-Gly-OH N-CBZ-Glycine N-Carbobenzyloxy-glycine |
| CAS | 1138-80-3 |
| EINECS | 214-516-0 |
| InChI | InChI=1/C10H11NO4/c12-9(13)6-11-10(14)15-7-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13)/p-1 |
N-Carbobenzyloxyglycine - Physico-chemical Properties
| Molecular Formula | C10H11NO4 |
| Molar Mass | 209.2 |
| Density | 1.2944 (rough estimate) |
| Melting Point | 117-121℃ |
| Boling Point | 424°C at 760 mmHg |
| Flash Point | 210.2°C |
| Water Solubility | Soluble in methanol. Insoluble in water. |
| Vapor Presure | 6.05E-08mmHg at 25°C |
| Appearance | White crystal |
| Storage Condition | Room Temprature |
| Refractive Index | 1.5400 (estimate) |
| MDL | MFCD00002691 |
| Physical and Chemical Properties | Melting Point 117-121°C |
| Use | Used as a polypeptide reagent |
N-Carbobenzyloxyglycine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R62 - Possible risk of impaired fertility R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
N-Carbobenzyloxyglycine - Upstream Downstream Industry
N-Carbobenzyloxyglycine - Security information
| WGK Germany | 3 |
| RTECS number | MB9129000 |
| TSCA | Yes |
| customs code | 29242995 |
Last Update：2024-04-10 22:29:15
N-Carbobenzyloxyglycine - Nature
| storage conditions | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear |
| acidity coefficient (pKa) | 3.98±0.10(Predicted) |
| morphology | Fine Crystalline Powder |
| color | White |
| water solubility | Soluble in methanol. Insoluble in water. |
| BRN | 526877 |
| InChIKey | CJUMAFVKTCBCJK-UHFFFAOYSA-N |
| EPA chemical information | Glycine, N-[(phenylmethoxy)carbonyl]- (1138-80-3) |
Last Update：2024-04-09 01:59:49
N-Carbobenzyloxyglycine - Uses and synthesis methods
use
1, used for polypeptide synthesis, used as amino acid protection monomer.
2. Organic intermediates.
3. Biochemical studies
4, for the synthesis of biochemical reagents, diazepam, fludiazepam, chlorprazolam mesylate and other peptides.
5, used as polypeptide reagent
production method
1. Under cooling, add benzyl chloroformate and sodium hydroxide solution dropwise to the mixture of glycine and sodium hydroxide solution while stirring vigorously. After the reaction, let it stand and separate the oil layer. The water layer is extracted with ether and then cooled and acidified to Congo red acid, the precipitate is filtered, washed and dried to obtain the product benzyloxycarbonylglycine. Yield 86-91%.
2. using benzyloxycarbonyl azide and glycine as raw materials, crude products are obtained by reaction under alkaline conditions, and then pure products are obtained by ether extraction and recrystallization.
category
Toxic substances
toxicity classification
Poisoning
acute toxicity
leaf sheath-mouse LD50: 380 mg/kg
flammability hazard characteristics
Thermal decomposition discharges toxic nitrogen oxide smoke
storage and transportation features
Warehouse low temperature ventilation and drying
fire extinguishing agent
Water, dry powder, carbon dioxide, foam
Last Update：2024-04-09 21:21:28
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Mobile: +8618958170122
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View History
N-Carbobenzyloxyglycine
3-Chloro-4-fluorophenylmagnesium bromide solution 0.5 in THF
3-氟-6-三氟甲基吡啶-2-甲腈
2-氨基-1,4-二甲氧基苯
螺[色烷-4,2'-环氧乙烷
3-Chloro-4-fluorophenylmagnesium bromide solution 0.5 in THF
3-氟-6-三氟甲基吡啶-2-甲腈
2-氨基-1,4-二甲氧基苯
螺[色烷-4,2'-环氧乙烷
Raw Materials for N-Carbobenzyloxyglycine
Downstream Products for N-Carbobenzyloxyglycine