N-ETHYL-2-CHLOROACETAMIDE
2-Chloro-N-ethylacetamide
CAS: 105-35-1
Molecular Formula: C4H8ClNO
N-ETHYL-2-CHLOROACETAMIDE - Names and Identifiers
| Name | 2-Chloro-N-ethylacetamide |
| Synonyms | TIMTEC-BB SBB008200 N-ETHYLCHLOROACETAMIDE N-ETHYL-2-CHLOROACETAMIDE 2-CHLORO-N-ETHYLACETAMIDE N-Ethyl-2-chloroacetamide 2-Chloro-N-ethylacetamide (N-CHLOROACETYL)ETHYL AMINE 2-chloro-N-ethyl-ethanamide Acetamide, 2-chloro-N-ethyl- .alpha.-Chloro-N-ethylacetamide |
| CAS | 105-35-1 |
| EINECS | 203-289-3 |
| InChI | InChI=1/C4H8ClNO/c1-2-6-4(7)3-5/h2-3H2,1H3,(H,6,7) |
N-ETHYL-2-CHLOROACETAMIDE - Physico-chemical Properties
| Molecular Formula | C4H8ClNO |
| Molar Mass | 121.57 |
| Density | 1.086±0.06 g/cm3(Predicted) |
| Melting Point | 129 °C(Solv: benzene (71-43-2)) |
| Boling Point | 96 °C(Press: 13 Torr) |
| Flash Point | 108.6°C |
| Vapor Presure | 0.0159mmHg at 25°C |
| pKa | 14.39±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.432 |
N-ETHYL-2-CHLOROACETAMIDE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
N-ETHYL-2-CHLOROACETAMIDE - Introduction
N-Ethyl-2-chloroacetamide is an organic compound with the chemical formula C4H8ClNO. The following is a description of its nature, use, preparation and safety information:
Nature:
N-ethyl-2-chloroacetamide is a colorless or yellowish liquid with a pungent odor. It has a high density, a melting point of -25°C and a boiling point of 217-220°C. It is sparingly soluble in water and readily soluble in organic solvents such as alcohols and ethers.
Use:
N-ethyl-2-chloroacetamide is widely used in organic synthesis. It is an important intermediate for the preparation of other organic compounds, and has a wide range of applications in the pharmaceutical, pesticide, dye and other industries. For example, it can be used in the synthesis of amine compounds, acylating reagents and thioesters in the field of medicine.
Preparation Method:
The preparation method of N-ethyl-2-chloroacetamide includes the reaction of ethanolamine and chloroacetic acid, usually under alkaline conditions. The specific preparation method can be adjusted according to actual needs, in general, the ethanolamine solution is added to chloroacetic acid, and the reaction temperature and reaction time are controlled to synthesize the target product.
Safety Information:
N-ethyl -2-chloroacetamide is an irritating and corrosive substance that has an irritating effect on the skin, eyes and respiratory tract. Appropriate protective equipment such as gloves, goggles and face shields should be worn during operation. Avoid contact with skin and eyes, and prevent inhalation of its vapors. Avoid fire and heat sources during storage and use, and keep away from oxidants. In case of leakage or accident, appropriate treatment measures shall be taken in time, such as ventilation, prevention of diffusion and pollutant source. At the same time, in view of the toxicity and danger of this compound, please handle it in a suitable laboratory environment and comply with relevant laboratory safety regulations.
Nature:
N-ethyl-2-chloroacetamide is a colorless or yellowish liquid with a pungent odor. It has a high density, a melting point of -25°C and a boiling point of 217-220°C. It is sparingly soluble in water and readily soluble in organic solvents such as alcohols and ethers.
Use:
N-ethyl-2-chloroacetamide is widely used in organic synthesis. It is an important intermediate for the preparation of other organic compounds, and has a wide range of applications in the pharmaceutical, pesticide, dye and other industries. For example, it can be used in the synthesis of amine compounds, acylating reagents and thioesters in the field of medicine.
Preparation Method:
The preparation method of N-ethyl-2-chloroacetamide includes the reaction of ethanolamine and chloroacetic acid, usually under alkaline conditions. The specific preparation method can be adjusted according to actual needs, in general, the ethanolamine solution is added to chloroacetic acid, and the reaction temperature and reaction time are controlled to synthesize the target product.
Safety Information:
N-ethyl -2-chloroacetamide is an irritating and corrosive substance that has an irritating effect on the skin, eyes and respiratory tract. Appropriate protective equipment such as gloves, goggles and face shields should be worn during operation. Avoid contact with skin and eyes, and prevent inhalation of its vapors. Avoid fire and heat sources during storage and use, and keep away from oxidants. In case of leakage or accident, appropriate treatment measures shall be taken in time, such as ventilation, prevention of diffusion and pollutant source. At the same time, in view of the toxicity and danger of this compound, please handle it in a suitable laboratory environment and comply with relevant laboratory safety regulations.
Last Update：2024-04-09 21:11:58
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