N-Methyldiethanolamine
N-Methyldiethanolamine
CAS: 105-59-9
Molecular Formula: C5H13NO2
N-Methyldiethanolamine - Names and Identifiers
| Name | N-Methyldiethanolamine |
| Synonyms | MDEA Methyl Diethanlamine METHYL DIETHANOLAMINE N-METHYLDIETHANOLAMINE N-Methyldiethanolamine N-Methyl Diethanolamine N-Methylediethanolamine 2,2-Methyliminodiethanol 2,2-(Methylimino)Diethanol N-METHYL-2,2'-IMINODIETHANOL BIS(2-HYDROXYETHYL)METHYLAMINE N-METHYL-2,2-IMINOBIS(ETHANOL) N,N-BIS(2-HYDROXYETHYL)METHYLAMINE N-METHYL-N-(2-HYDROXYETHYL)-2-AMINOETHANOL 2-hydroxy-N-(2-hydroxyethyl)-N-methylethanaminium |
| CAS | 105-59-9 |
| EINECS | 203-312-7 |
| InChI | InChI=1/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3/p+1 |
| InChIKey | CRVGTESFCCXCTH-UHFFFAOYSA-N |
N-Methyldiethanolamine - Physico-chemical Properties
| Molecular Formula | C5H13NO2 |
| Molar Mass | 119.16 |
| Density | 1.038g/mLat 25°C(lit.) |
| Melting Point | -21 °C |
| Boling Point | 246-248°C(lit.) |
| Flash Point | 260°F |
| Water Solubility | MISCIBLE |
| Vapor Presure | 0.01 mm Hg ( 20 °C) |
| Vapor Density | 4 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless to light yellow |
| Odor | Ammonical |
| BRN | 1734441 |
| pKa | 14.41±0.10(Predicted) |
| PH | 11.5 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Explosive Limit | 0.9-8.4%(V) |
| Refractive Index | n20/D 1.469(lit.) |
| Physical and Chemical Properties | colorless or yellowish viscous liquid |
| Use | It is a new solvent with excellent performance for selective desulfurization and decarburization. It has the advantages of high selectivity, less solvent consumption, remarkable energy saving effect, and not easy to degrade. Widely used in oil gas and gas desulfurization purification emulsifier and acid gas absorbent, acid-base control agent, polyurethane foam catalyst. The carbon dioxide in synthetic ammonia can be removed with the participation of an activator, so that it has been gradually promoted in the absorption of carbon dioxide in flue gas in recent years. In addition, MDEA can also be used as pesticides, emulsifiers, semi-finished products of fabric additives, intermediates of antineoplastic drug hydrochloric acid nitrogen mustard, catalyst of carbamate coatings, it is also a drying accelerator for paint. |
N-Methyldiethanolamine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 24 - Avoid contact with skin. |
| UN IDs | 2735 |
| WGK Germany | 1 |
| RTECS | KL7525000 |
| TSCA | Yes |
| HS Code | 2922 17 00 |
| Hazard Class | 8 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 4680 mg/kg |
N-Methyldiethanolamine - Nature
Open Data Verified Data
colorless or dark yellow oily liquid. Freezing point -21 °c. Boiling point 247.2 °c. Flash point 260 °c. The relative density was 1. 0377. Refractive index 4678. Miscible with water and alcohol. Slightly soluble in ether.
Last Update：2024-01-02 23:10:35
N-Methyldiethanolamine - Preparation Method
Open Data Verified Data
ethylene oxide is reacted with methylamine at a temperature of 100 ° C. To 170 ° C. And a pressure of 0588 MPA to 9.8066MPA, followed by distillation and rectification to obtain a finished N-methyldiethanolamine. In addition, formaldehyde and cyanoethanol as raw materials, through catalytic hydrogenation, or formaldehyde and diethanolamine can be obtained
N-methyldiethanolamine.
Last Update：2022-01-01 10:35:25
N-Methyldiethanolamine - Application
Open Data Verified Data
It is mainly used as an emulsifier and an absorbent of acid gas, and is also used as an intermediate for antitumor drugs.
Last Update：2025-08-19 16:24:40
N-Methyldiethanolamine - Safety
Open Data Verified Data
for rats, the oral LD50 was 4.78 mg/kg.
Last Update：2022-01-01 10:35:26
N-Methyldiethanolamine - Reference Information
| pH range of acid-base indicator discoloration | 11.5 at 100g/l at 20°C |
| LogP | -1.16 at 23℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| purpose | mainly used as emulsifier and acid gas absorbent, acid-base control agent, polyurethane foam catalyst. It is also used as an intermediate of the antitumor drug nitrogen hydrochloride and the like. |
| production method | 1. From the reaction of formaldehyde and diethanolamine. Formic acid was added to the reaction pot and heated to boiling, and a mixed solution of formaldehyde and diethanolamine was added dropwise under stirring for about 1H. The temperature was maintained at 90-98 ° C., and reflux was continued for 4 hours. Then, distillation under reduced pressure was carried out to collect a fraction at 120-130 ° C. (0.53kPa) to obtain N-methyldiethanolamine in a yield of 85%. Derived from the reaction of methylamine with ethylene oxide. The temperature was kept below 30 ° C., and the addition reaction was carried out by introducing ethylene oxide gas into 20% methylamine solution until the relative density of the reaction solution reached 1.025. Stirring for 15min, the relative density is unchanged for the end point. Methylamine was recovered to 103 ° C. Under normal pressure, and after water was evaporated under reduced pressure, a 119-170 ° C. (4.67kPa) fraction was collected. It is the finished product. The yield was 72%. Raw material consumption quota: Ethylene oxide 950kg/t, methylamine (40%)870kg/t. In addition, N-methyl diethanolamine can be obtained by catalytic hydrogenation of formaldehyde and cyanoethanol. |
| spontaneous combustion temperature | 770 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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