N-carbamyl-L-glutamic
N-carbamyl-L-glutamic acid
CAS: 1188-38-1
Molecular Formula: C6H10N2O5
N-carbamyl-L-glutamic - Names and Identifiers
N-carbamyl-L-glutamic - Physico-chemical Properties
| Molecular Formula | C6H10N2O5 |
| Molar Mass | 190.15 |
| Density | 1.499±0.06 g/cm3(Predicted) |
| Melting Point | 174° |
| Boling Point | 438.1±45.0 °C(Predicted) |
| Flash Point | 218.8°C |
| Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| Vapor Presure | 6.7E-09mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 3.71±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 1.544 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Carglumic acid suppresses cell viability in the pancreatic ductal adenocarcinoma cell lines, triple-negative breast cancer cell lines, hepatoma cell lines, and human non-small cell lung carcinoma cell lines in a dose-dependent manner. The 50% inhibitory concentration (IC 50 ) of Carglumic acid against those cell lines is between 5 and 7.5 mM. The results show that Carglumic acid does not induce complete cell cycle arrest. Instead, there are more sub-G1 cells among Carglumic acid-treated AsPC1 and MDA-MB-231 cells than among untreated cells. In AsPC1 and HPDE-E6E7 cells, the IC 50 s of Carglumic acid are 5 mM and over 10 mM, respectively . In MDA-MB-231 and MCF-12A cells, the IC 50 s of Carglumic acid are 5 mM and 6 mM, respectively. |
| In vivo study | The results show that Carglumic acid, but not the vehicle control, markedly inhibits tumor growth. In the orthotopic pancreatic cancer model, tumor growth inhibition by Carglumic acid on day 21 is 80% (P<0.01). In the orthotopic triple-negative breast cancer model, tumor growth inhibition by Carglumic acid on day 20 is 82% (P<0.01). These results indicate that Carglumic acid suppresses tumor growth in pancreatic cancer and triple-negative breast cancer. On day 20, mean tumor growth inhibition in orally and intravenously treated mice is 55% and 93%, respectively, relative to untreated mice (P<0.01). |
N-carbamyl-L-glutamic - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| RTECS | LZ9870000 |
| HS Code | 2924190002 |
N-carbamyl-L-glutamic - Reference Information
| Use | N-carbamoyl-L-glutamic acid has been shown to have a protective effect on ammonia poisoning and is used to treat acute hyperammonemia. |
| Biological activity | Carglumic acid (N-Carbamyl-L-glutamic acid) is a functional analog of N-acetylglutamate (NAG) and an activator of carbamyl phosphate synthase 1 (CPS1), used to study acute and chronic hyperammonemia related to N-acetylglutamate synthase (NAGS) deficiency. |
| target | CPS1 |
Last Update：2024-04-09 21:54:55
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