NADOLOL
NADOLOL
CAS: 42200-33-9
Molecular Formula: C17H27NO4
NADOLOL - Names and Identifiers
NADOLOL - Physico-chemical Properties
| Molecular Formula | C17H27NO4 |
| Molar Mass | 309.4 |
| Density | 1.0449 (rough estimate) |
| Melting Point | 125-130°C |
| Boling Point | 449.67°C (rough estimate) |
| Water Solubility | 8.30g/L(25 ºC) |
| Solubility | Slightly soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in acetone. |
| Appearance | neat |
| Color | White to Off-White |
| pKa | 9.67(at 25℃) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.5420 (estimate) |
| Physical and Chemical Properties | Crystalline powder. Melting point 124-136 ℃, soluble in alcohol, slightly soluble in chloroform, insoluble in acetone, benzene. |
| In vitro study | In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a K i value of 19.4 μM. With respect to Nadolol, the K m for OATP1A2 is 84 μM. |
| In vivo study | In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress. |
NADOLOL - Risk and Safety
| WGK Germany | 2 |
| RTECS | QJ4870000 |
| HS Code | 2922190900 |
| Toxicity | LD50 in mice, rats (mg/kg): 4500, 5300 orally (Antonaccio, Evans) |
NADOLOL - Reference Information
| biological activity | Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective β-adrenergic receptor antagonist with antihypertensive and antiarrhythmic activity. |
| target | TargetValue β-adrenergic receptor () |
| Target | Value |
| in vitro study | in human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a k I value of 19.4 μ m. with respect to Nadolol, the k m for OATP1A2 is 84 μ m. |
| in vivo study | in male OF1 bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress. |
| chemical properties | crystalline powder. Melting point 124-136 ℃, soluble in alcohol, slightly soluble in chloroform, insoluble in acetone and benzene. |
| use | antiarrhythmic drugs. |
| production method | cis -5,6,7,8-tetrahydro -1,6,7-naphthol (melting point 188-188.5 ℃) is prepared from 5,8-dihydro -1-naphthol, and then react with sodium methoxide, dimethyl sulfoxide and 3-chloro -1,2-propylene oxide to produce 2,3-cis -1,2,3,4-tetraoxy -5-[2,3-(epoxy) propoxy]-2,3-naphthol diol, and then react with tert-butylamine to obtain naphthalene hydroxy. |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:44:15
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QQ: 2881950922
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