NONOXYNOL
Tergitol(R) NP-10 (nonionic)
CAS: 26027-38-3
Molecular Formula: C17H35O4S.Na
NONOXYNOL - Names and Identifiers
| Name | Tergitol(R) NP-10 (nonionic) |
| Synonyms | Nonoxynol NONOXYNOL-1 igepal co-990 igepal co-520 Igepal?CO-890 Igepal?CO-720 Igepal?CO-210 NONOXYNOL-120 Igepal?CO-990 igepal co-890 NONOXYNOL-100 igepal co-720 Tergitol(R) NP-10 (nonionic) ammonium 2-(4-nonylphenoxy)ethyl sulfate Polyethylen Glycol Monononylphenol Ether Polyethylene glycol mono-4-nonylphenyl ether sodium 1-nonyl-2-(2-nonylphenoxy)benzene sulfate |
| CAS | 26027-38-3 |
| EINECS | 500-045-0 |
| InChI | InChI=1/C30H46O.C2H6O2.10C2H4/c1-3-5-7-9-11-13-15-17-27-19-23-29(24-20-27)31-30-25-21-28(22-26-30)18-16-14-12-10-8-6-4-2;3-1-2-4;10*1-2/h19-26H,3-18H2,1-2H3;3-4H,1-2H2;10*1-2H2 |
| InChIKey | HNLXNOZHXNSSPN-UHFFFAOYSA-N |
NONOXYNOL - Physico-chemical Properties
| Molecular Formula | C17H35O4S.Na |
| Molar Mass | 765.285 |
| Density | 1.00 |
| Melting Point | 57-58℃ |
| Boling Point | 30℃ |
| Flash Point | >150℃ |
| Water Solubility | 1g/L |
| Solubility | Miscible with water, with ethanol (96 per cent) and with vegetable oils. |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | powder to lump to clear liquid |
| Color | Almost colorless liquid |
| Merck | 14,6677 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4950-1.4990 |
NONOXYNOL - Risk and Safety
| RTECS | MD0906000 |
| Toxicity | otr-mus:fbr 10 ppm CRNGDP 3,553,82 |
NONOXYNOL - Standard
Authoritative Data Verified Data
This product is nonylphenol and ethylene oxide condensation from the anhydrous mixture. The content of C9H19C6H4(OCH2CH2)2OH (in the formula, the average value of n is 9) should be 90.0% to 110.0%.
Last Update：2024-01-02 23:10:35
NONOXYNOL - Trait
Authoritative Data Verified Data
- This product is colorless to light yellow viscous liquid; Odorless; Easy to coagulate below 10°C.
- This product is easily soluble in ethanol and soluble in water.
melting point
take this product l. Add 100ml of water to a 250ml beaker, soak the thermometer in the center of the solution, heat the solution in a water bath with constant stirring until the solution is turbid, then raise the temperature to 10°C, and remove the water bath, keep stirring until the solution is clear (the thermometer mercury ball is fully visible), record the temperature at this point, which should be 52-56°C.
acid value
The acid value of this product (General 0713) is not more than 0.2.
Last Update：2022-01-01 11:32:30
NONOXYNOL - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 43).
Last Update：2022-01-01 11:32:31
NONOXYNOL - Exam
Authoritative Data Verified Data
polyethylene glycol
Take 10g of this product, weigh it accurately, put it in a 250ml beaker, add 100ml of ethyl acetate to dissolve it, transfer it to a 500ml separatory funnel, add 100ml of 30% sodium chloride solution, shake it for 1 min, insert a thermometer, and then immerse the separating funnel in a water bath at 50°C, slowly turn to make the layers. When the temperature reaches 40-50°C, remove the separating funnel and separate the sodium chloride liquid layer, in another 500ml separating funnel; The ethyl acetate liquid layer is extracted once with 30% ml of sodium chloride solution according to the above method, and the sodium chloride liquid is combined and washed once with ethyl acetate according to the above method, the sodium chloride solution layer was extracted twice with chloroform shaking, 100ml each time, and the chloroform solution was combined, filtered, and the filtrate was placed in a 250ml beaker, evaporated to dryness on a water bath, let it cool, and add 200ml of acetone to dissolve, filter, and wash with acetone 2 times, 25ml each time, combine the filtrate and wash solution, put in a pre-constant weight and weight of 250ml beaker, put in water bath to dry, drying under reduced pressure at 60°C for 1 hour, cooling, precision weighing, containing polyethylene glycol should not exceed 1.6%.
residual solvent
5.0g of the product was accurately weighed with dioxane, placed in a 20ml headspace bottle, sealed, and used as a test solution; The other precision weighed an appropriate amount of dioxane, add nonoxynol ether volatilized at 160°C for 5 hours, fully shake to mix evenly, and make a solution containing 5ug dioxane per lg quantitatively, weigh 5.0g accurately, A 20ml headspace bottle was placed, sealed, and used as a control solution. According to the test of gas chromatography (General 0521), using ethyl ethylene-divinylbenzene copolymer as filler, the column temperature is 160°C, the inlet temperature is 200°C, and the detector temperature is 200°C, the Headspace bottle equilibration temperature was 130°C and the equilibration time was 30 minutes. The test solution and the reference solution were injected by Headspace, and the chromatograms were recorded. The content of dioxane shall not exceed 0.0005% calculated by peak area according to external standard method.
free ethylene oxide
Take 5.0g of this product with precision, put it in a 20ml headspace bottle, seal it, and use it as a test solution. Take an appropriate amount of calibrated ethylene oxide stock solution with precision, add nonoxynol ether volatilized at 150°C for 3 hours (ethylene oxide shall not be detected according to the following gas chromatography method), and fully shake in an ice bath to make it well mixed, and make a quantitative solution containing lug of ethylene oxide in each lg, weigh 5.0g accurately, put it in a 20ml headspace bottle, seal it, and use it as a reference solution; Then take the appropriate amount of acetaldehyde and ethylene oxide stock solution, add to nonoxynol ether volatilized at 150°C for 3 hours, dilute to make a solution containing about 10ug of acetaldehyde and 10ug of ethylene oxide in each lml, weigh 5.0g, put it in a 20ml headspace bottle, and seal it, as a system suitability test solution. According to the test of gas chromatography (General 0521), a capillary column with 6% cyanopropyl phenyl-94% dimethyl polysiloxane as stationary liquid is used, and the initial temperature is 50°C, and the retention time is 7 minutes, then the temperature is increased to 200°C at a rate of 80°C per minute for 8 minutes, the temperature of the injection port is 200°C, the temperature of the detector is 250°C, and the equilibrium temperature of the headspace bottle is 100°C, the equilibration time was 30 minutes. The system applicability test solution is sampled in the headspace, the chromatogram is recorded, and the separation degree of acetaldehyde peak and ethylene oxide peak shall meet the requirements. Then take the test solution and the reference solution, respectively headspace injection, record the chromatogram, according to the external standard method based on peak area calculation, containing free ethylene oxide not more than 0.0001%.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 0.5%.
Last Update：2022-01-01 11:32:32
NONOXYNOL - Content determination
Authoritative Data Verified Data
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-water (88:12) as mobile phase; The detection wavelength was 280mn. The number of theoretical plates is not less than 1000 based on the nonoxynol ether peak.
- determination method: take about 0.1kg of this product, weigh it accurately, put it in a 100ml measuring flask, add the mobile phase to dissolve and dilute to the scale, shake it well, and use it as a test solution, 10u1 was injected into the liquid chromatograph for precise measurement, and the chromatogram was recorded. Nonoxynol ether reference substance was taken for the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:32:32
NONOXYNOL - Category
Authoritative Data Verified Data
surfactant, spermicidal.
Last Update：2022-01-01 11:32:33
NONOXYNOL - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:32:33
NONOXYNOL - Attached: Ethylene oxide stock solution
Authoritative Data Verified Data
formulation
take 25ml of epoxy ethylene glycol, place it in a 500ml measuring flask containing about 100ml of isopropanol, shake well, dilute it with isopropanol to the scale, and shake well to obtain it. Each 1 ml contains about 44mg of ethylene oxide. The patient was placed in refrigerator for storage and was calibrated on the same day.
calibration
take 25ml of 0.5mol/L hydrochloric acid ethanol solution, place it in a 40g Erlenmeyer flask containing magnesium chloride, shake well to fully saturate, and then add 10ml of ethylene oxide stock solution, 1ml of bromocresol green indicator solution was added dropwise. If the solution does not show yellow color, continue to add 10ml of the above 0.5mol/L hydrochloric acid ethanol solution accurately, plug and place for 30 minutes. Titration with potassium hydroxide titration solution (0.5mol/L), and the titration results with isopropanol 10ml as a blank test correction. Each 1ml of ethanol to potassium hydroxide titration solution (0.5mol/L) corresponds to 22.02mg of ethylene oxide.
note
The equipment and test solution for preparation and calibration need to be cooled by ice bath before use; Cooling should be paid attention to in the process of preparation and calibration.
Last Update：2022-01-01 11:32:34
NONOXYNOL - Nonoxynol vaginal tablets
Authoritative Data Verified Data
This product contains nonoxynol ether (C33H60O10) should be 90.0% to 110.0% of the label.
trait
This product is white tablet.
identification
- Take 2 tablets of this product, add 10ml of water to dissolve nonoxynol ether, filter, take 2ml of filtrate, add 3 drops of hydrochloric acid and sodium chloride about 0.1g, dissolve, add 3 drops of potassium ferrocyanide test solution, that is, a white precipitate was formed.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of the fine powder of this product, add an appropriate amount of water, shake to dissolve nonoxynol ether, dilute with water to make a solution containing 0.2mg nonoxynol ether per 1 ml, filter, the filtrate was measured by UV-Vis spectrophotometry (General 0401), and the maximum absorption was found at the wavelength of 275nm.
examination
- Take 3 tablets of this product, add water 30ml, shake to dissolve nonoxynol ether, filter, take the filtrate, according to the law (General 0631),pH value should be 6.0~8.0.
- disintegration time and foam volume: Take 6 measuring cylinders of 25ml, add 3ml of water respectively, and put them in a constant temperature water bath at 37°C until the temperature is constant, 1 tablet of this product (the tablet is wound into mesh with 16cm long 22# lead wire to prevent the tablet from floating with the foam when it disintegrates), and the time is recorded. The tablet should be completely disintegrated within 5 minutes, and the amount of rise of the foam should be not less than 15ml.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 10 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about 0.1g equivalent to nonoxynol ether), put it in a 100ml measuring flask, add appropriate amount of mobile phase, shake for 15 minutes to dissolve nonoxynol ether, dilute to the scale with mobile phase, shake, filter, take the continued filtrate as a test solution, take 10 u1 with precision, and measure according to the method under the determination of nonoxynol ether content.
category
Same as nonoxynol ether.
specification
0.lg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:32:34
NONOXYNOL - Nonoxynol ether suppositories
Authoritative Data Verified Data
This product contains nonoxynol ether (C33H60010) should be the label amount of 90.0% ~ 115.0%.
trait
This product is white or milky white suppository.
identification
- take 1 capsule of this product, add 10ml of water to dissolve nonoxynol ether, filter, take 2ml of filtrate, add 3 drops of hydrochloric acid and 0.lg of sodium chloride, add 3 drops of potassium ferrocyanide test solution after dissolution, and generate white precipitate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- acidity: Take 3 grains of this product, add 30ml of water, heat it in a water bath at 40°C to dissolve it, and measure it according to law (General rule 0631). The pH value should be 3.5~7.0. The melting time limit is 25 minutes, which shall be in accordance with the regulations (General rule 0922).
- others should comply with the relevant provisions under suppository (General rule 0107).
Content determination
Take 10 grains of this product, weigh it accurately, cut it into fragments, weigh an appropriate amount (about 50mg of nonoxynol ether), put it in a small beaker, add 20ml of methanol, dissolve nonoxynol ether in a water bath at 40-50°C, transfer it to a 50ml measuring flask, let it cool, dilute it to scale with methanol, shake it, place it, and take the supernatant as the test solution, precision measure l0ul, according to the method under the determination of nonoxynol ether content, obtained.
category
Same as nonoxynol ether.
specification
(l )50mg (2)100mg
storage
light shielding, closed storage.
Last Update：2022-01-01 11:32:35
NONOXYNOL - Nonoxinol Pellicles
Authoritative Data Verified Data
This product contains nonoxynol ether (C33H60010) should be the label amount of 90.0% ~ 115.0%.
trait
This product is white-like to yellowish translucent film, soluble in water.
identification
- take an appropriate amount of this product (about 50mg equivalent to nonoxynol ether), add 5ml of water, 5 drops of hydrochloric acid and 0.lg of sodium chloride, shake to dissolve, add 2ml of potassium ferrocyanide test solution, and white precipitate will occur.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- acidity: take an appropriate amount of this product (about 50mg equivalent to nonoxynol ether), add 10ml of water to dissolve it, and measure it according to law (General rule 0631). The pH value should be 5.0~7.0.
- during the melting time, take 10 sheets of the drug film, one sheet at a time and fold it in half three times (I. E., fold it into 1/8 of the original area), and use a clip with a mouth width of about 3.5cm, clamp the drug film at the dispersion, with the clip immersed in a 37°C water bath, with a stop watch time, the film from immersion in human water to dissolve and break off the time of the clip, should not exceed 3 minutes.
- others shall comply with the relevant provisions under the film (General 0125).
Content determination
Take 20 sheets of this product, precisely weigh it, cut it into fragments, precisely weigh an appropriate amount (about 0.1g of nonoxynol ether), put it in a 100ml measuring flask, add an appropriate amount of water to dissolve the nonoxynol ether, and dilute it to the scale, shake, filter, take the continued filtrate as the test solution, take the L01 with precision, and measure it according to the method under the determination of nonoxynol ether content.
category
Same as nonoxynol ether.
specification
each film contains nonoxynol ether 50mg ( 5cm X 5cm,7cm X 5cm, 10cm X 5cm)
storage
sealed, stored in a cool and dry place.
Last Update：2022-01-01 11:32:36
NONOXYNOL - Reference Information
| LogP | 4.48 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | nonoxynyl alcohol ether, also known as Lele ether, is a non-ionic surfactant and is currently the most commonly used external spermaticide. The main function is to reduce the surface tension of the sperm lipid membrane, change the osmotic pressure of the sperm and kill the sperm or cause the sperm to be unable to swim, lose the ability to move, so that the sperm cannot enter the cervix, and the egg cannot be fertilized to achieve the purpose of contraception. |
| Pharmacological effects | Nonoxynol ether is a non-ionic surfactant. Its main function is to reduce the surface tension of the sperm lipid membrane and change the osmotic pressure of the sperm. Sperm or cause the sperm to be unable to swim, so that the sperm cannot enter the cervix, cannot fertilize the egg, and achieve the purpose of contraception. The nonoxynol ether contraceptive film is dissolved into gel (about 5min) after being placed deep in the vagina, and the effect is maintained for about 1-2h. The suppository took effect for 10min and the effect was maintained for 2-10h. |
| use | nonylphenol polyoxyethylene ether (NPEOn) is the most widely used alkylphenol polyoxyethylene ether, accounting for about 80% of its output. it is the second largest nonionic surfactant after fatty alcohol polyoxyethylene ether (APE). Emulsion polymerization and polymer stabilizers in plastics and synthetic rubbers, textile processing, agricultural chemicals, pulp and paper processes, metal and mineral processing, latex coatings, wetting agents and emulsifiers, foaming agents, inks, Adhesives and medicines, as well as commercial laundry detergents, apartment cleaning products and vehicle cleaning agents. |
| Biological activity | 4-Nonylphenol polyethoxylate is a surfactant, often used as a spermicide in contraceptives. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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