NP118809
NP118809
CAS: 41332-24-5
Molecular Formula: C32H32N2O
NP118809 - Names and Identifiers
NP118809 - Physico-chemical Properties
| Molecular Formula | C32H32N2O |
| Molar Mass | 460.61 |
| Density | 1.142±0.06 g/cm3(Predicted) |
| Boling Point | 618.9±55.0 °C(Predicted) |
| pKa | 5.99±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | NP118809 is a potent N-type calcium channel blocker, with an IC 50 of 0.11 μM; also inhibits L-type calcium channel with an IC 50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC 50 of 7.4 μM. |
| In vivo study | NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model. |
NP118809 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.171 ml | 10.855 ml | 21.71 ml |
| 5 mM | 0.434 ml | 2.171 ml | 4.342 ml |
| 10 mM | 0.217 ml | 1.086 ml | 2.171 ml |
| 5 mM | 0.043 ml | 0.217 ml | 0.434 ml |
Last Update：2024-01-02 23:10:35
NP118809 - Reference Information
| biological activity | NP118809 is an effective n-type calcium channel (N-type calcium channel) blocker with an IC50 value of 0.11 μM; At the same time, it can weakly inhibit l-type calcium channel (L-type calcium channel) with an IC50 value of 12.2 μM. |
| target | N-Type Ca 2 + Channel 0.11 μM (IC 50 ) L-type calcium channel 12.2 μM (IC 50 ) |
| in vitro study | NP118809 is a potent N-type calcium channel blocker, with an IC 50 of 0.11 μ M; Also inhibits L-type calcium channel with an IC 50 of 12.2 μ M. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC 50 of 7.4 μ m. |
| in vivo study | NP118809 (25 mg/kg, I. p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, P. o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model. |
Last Update：2024-04-09 02:00:00
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Tel: 609-228-6898
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Product Name: NP118809 Visit Supplier Webpage Request for quotation
CAS: 41332-24-5
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CAS: 41332-24-5
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