NSC348884
NSC348884
CAS: 81624-55-7
Molecular Formula: C38H40N10
NSC348884 - Names and Identifiers
NSC348884 - Physico-chemical Properties
| Molecular Formula | C38H40N10 |
| Molar Mass | 636.79 |
| Density | 1.347 |
| Boling Point | 1001.7±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 34 mg/mL |
| pKa | 11.61±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | NSC348884 inhibits nucleolar phosphoprotein by disrupting a hydrophobic structure used in the Oligomerization reaction. By polyacrylamide gel electrophoresis analysis found that it can break the nucleolar protein phosphate oligomer formation. NSC348884 can up-regulate p53 and induce apoptosis. |
| In vivo study | Injection of NSC348884 in tumor-bearing mice significantly inhibited tumor invasion and intravascular infiltration. Compared with the control group, there was no significant difference in cell necrosis in the experimental group treated with 4H NSC348884, suggesting that the small molecule specifically inhibited its migration process. |
NSC348884 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.57 ml | 7.852 ml | 15.704 ml |
| 5 mM | 0.314 ml | 1.57 ml | 3.141 ml |
| 10 mM | 0.157 ml | 0.785 ml | 1.57 ml |
| 5 mM | 0.031 ml | 0.157 ml | 0.314 ml |
Last Update：2024-01-02 23:10:35
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