NadifloxacinAPI
Nadifloxacin
CAS: 124858-35-1
Molecular Formula: C19H21FN2O4
NadifloxacinAPI - Names and Identifiers
| Name | Nadifloxacin |
| Synonyms | NDFX Acuati 124858-35-1 NADIFLOXACIN Jinofloxacin Nadifloxacin Nadifiloxacin NadifloxacinAPI 9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic Acid (±)-9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic Acid 9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid |
| CAS | 124858-35-1 |
| EINECS | 638-863-6 |
| InChI | InChI=1/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26) |
NadifloxacinAPI - Physico-chemical Properties
| Molecular Formula | C19H21FN2O4 |
| Molar Mass | 360.38 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Melting Point | 245-2470C (dec) |
| Boling Point | 624.9±55.0 °C(Predicted) |
| Flash Point | 331.7°C |
| Solubility | DMSO (Slightly), Methanol (Sparingly, Heated) |
| Vapor Presure | 1.77E-16mmHg at 25°C |
| Appearance | off-white crystalline solid |
| Color | White to Off-White |
| Merck | 14,6345 |
| pKa | 5.55±0.40(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.668 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vivo study | Nadifloxacin can inhibit DNA gyrase activity involved in bacterial DNA synthesis and replication, thereby inhibiting bacterial proliferation. In vitro studies have shown that Nadifloxacin has a broad spectrum of antibacterial effect on aerobic Gram-positive bacteria, gram-negative bacteria and anaerobic bacteria are effective. In addition, studies have shown that naditoxin is also effective in inflammatory acne lesions, which may be related to its inhibitory effect on pro-inflammatory cytokines, such as interleukin (IL)-1α, IL-6 and IL-8, these factors play an important role in the pathogenesis of acne. |
NadifloxacinAPI - Risk and Safety
| Toxicity | LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto) |
NadifloxacinAPI - Reference
| Reference Show more | 1. [IF=6.057] Song Hu et al."Reliable performance of aggregation-induced emission nanoparticle-based lateral flow assay for norfloxacin detection in nine types of animal-derived food."Talanta. 2020 Nov;219:121245 |
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