Neostigmine

Name	Neostigmine
Synonyms	Eustigmin Eustigmine Neostigmine Neostygmine Vagostigmine 3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium
CAS	59-99-4

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
neostigmine test	myasthenia gravis (MG) is an autoimmune disease mediated by acetylcholine receptor antibodies, cellular immune dependence, complement participation, acquired autoimmune disease mainly involving the postsynaptic membrane acetylcholine receptor of neuromuscular junction, and finally the acetylcholine transmission function is weakened, which leads to the fatigue weakness of voluntary muscles, neostigmine as an acetylcholinesterase inhibitor can reduce the degradation of acetylcholine in the synaptic cleft of peripheral nerve, increase its content, restore muscle muscle strength, therefore, the clinical commonly used neostigmine test to determine whether the patient's muscle weakness is caused by the neuromuscular contact acetylcholine receptor involvement, so the neostigmine test positive for MG diagnosis has a great auxiliary role.
category	toxic substances
toxicity grade	highly toxic
Acute toxicity	intravenous-rat LD50: 0.225 mg/kg; Intravenous-mouse LD50: 0.380 mg/kg
flammability hazard characteristics	flammable, combustion decomposition of toxic nitrogen oxide gases
storage and transportation characteristics	The warehouse is low temperature, ventilated and dry, and stored separately from food raw materials
extinguishing agent	water, carbon dioxide, dry powder, sand
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)