Name | Neostigmine |
Synonyms | Eustigmin Eustigmine Neostigmine Neostygmine Vagostigmine 3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium |
CAS | 59-99-4 |
Molecular Formula | C12H19N2O2 |
Molar Mass | 223.294 |
Density | 1.0718 (rough estimate) |
Boling Point | 364.59°C (rough estimate) |
Refractive Index | 1.4760 (estimate) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
neostigmine test | myasthenia gravis (MG) is an autoimmune disease mediated by acetylcholine receptor antibodies, cellular immune dependence, complement participation, acquired autoimmune disease mainly involving the postsynaptic membrane acetylcholine receptor of neuromuscular junction, and finally the acetylcholine transmission function is weakened, which leads to the fatigue weakness of voluntary muscles, neostigmine as an acetylcholinesterase inhibitor can reduce the degradation of acetylcholine in the synaptic cleft of peripheral nerve, increase its content, restore muscle muscle strength, therefore, the clinical commonly used neostigmine test to determine whether the patient's muscle weakness is caused by the neuromuscular contact acetylcholine receptor involvement, so the neostigmine test positive for MG diagnosis has a great auxiliary role. |
category | toxic substances |
toxicity grade | highly toxic |
Acute toxicity | intravenous-rat LD50: 0.225 mg/kg; Intravenous-mouse LD50: 0.380 mg/kg |
flammability hazard characteristics | flammable, combustion decomposition of toxic nitrogen oxide gases |
storage and transportation characteristics | The warehouse is low temperature, ventilated and dry, and stored separately from food raw materials |
extinguishing agent | water, carbon dioxide, dry powder, sand |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |