OLIGOMYCIN
Oligomycin
CAS: 1404-19-9
Molecular Formula: C135H220O33
OLIGOMYCIN - Names and Identifiers
| Name | Oligomycin |
| Synonyms | Oligomycin Nystatin dehydrate diastatochromogenes OligomycinABCcomplex OLIGOMYCIN, MIXTURE OF A, B AND C OLIGOMYCIN FROM STREPTOMYCES*DIASTATOCHR OMOGENE oligomycin from streptomyces diastatochromogenes OLIGOMYCIN, MIXTURE OF THE COMPONENTS A, B AND C OLIGOMYCIN, MIXTURE OF A, B AND C, FROM STREPTOMYCES DIASTATOCHROMOGENES |
| CAS | 1404-19-9 |
| EINECS | 215-767-9 |
| InChI | InChI=1/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+ |
OLIGOMYCIN - Physico-chemical Properties
| Molecular Formula | C135H220O33 |
| Molar Mass | 2371.1715 |
| Density | 1.143 g/cm3 |
| Melting Point | 84-100 °C |
| Boling Point | 886.3°C at 760 mmHg |
| Flash Point | 252°C |
| Water Solubility | Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n |
| Solubility | Soluble in EtOH, acetone (50 mg/ml), DMSO (300 mg/ml), ethanol, and methanol. Insoluble |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Powder |
| Color | White |
| BRN | 7615308 |
| Storage Condition | −20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.543 |
| MDL | MFCD01779388 |
| Use | A specific inhibitor of the mitochondrial ATP-synthase. |
| In vitro study | Oligomycin, inhibitor of the F0 part of H + -ATP-synthase, suppresses the TNF-induced apoptosis. |
OLIGOMYCIN - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | RK3325000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29419090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
OLIGOMYCIN - Reference
| Reference Show more | 1. Zi Youmei, Huang Yan, Zhang Yuan, et al. Berberine selectively induces apoptosis of lymphoma cells by destroying mitochondrial function [J]. Chinese Journal of Pharmacology and Toxicology, 2020, v.34(01):32-39. |
OLIGOMYCIN - Reference Information
| Biological activity | Oligomycin is an antifungal antibiotic and an inhibitor of H -ATP synthase. Oligomycin oxidative phosphorylation and electron transport chains. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. |
| Use | is one of the inhibitors of oxidative phosphorylation energy transfer, and the Fo part of the proton pump (H ATP) (The part of the membrane that penetrates H) can specifically inhibit the transport of H, so it also inhibits the synthesis and decomposition of ATP. In biochemical research, it can be used as an inhibitor of oxidative phosphoric acid, so that electron transfer cannot be carried out, which directly interferes with the production process of ATP; oligomycin D, antifungal. |
Last Update：2024-04-09 21:21:28
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