Ozanimod
Ozanimod
CAS: 1306760-87-1
Molecular Formula: C23H24N4O3
Ozanimod - Names and Identifiers
Ozanimod - Physico-chemical Properties
| Molecular Formula | C23H24N4O3 |
| Molar Mass | 404.4617 |
| Density | 1.30±0.1 g/cm3(Predicted) |
| Melting Point | 134-137°C |
| Boling Point | 648.3±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 29 mg/mL |
| Appearance | Form Solid, color White to Off-White |
| pKa | 14.73±0.10(Predicted) |
| Storage Condition | -20°C Freezer |
| Physical and Chemical Properties | Bioactive Ozanimod (RPC1063) is a selective oral S1P Receptor 1 regulator. |
| Use | Ozamod is mainly used in the treatment of multiple sclerosis, ulcerative colitis and Crohn's disease. Among them, multiple sclerosis and ulcerative colitis not only have a long course and a high incidence, but also require long-term medication. It can be seen that Ozamod's market capacity is huge and the prospects are promising. |
Ozanimod - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.472 ml | 12.362 ml | 24.724 ml |
| 5 mM | 0.494 ml | 2.472 ml | 4.945 ml |
| 10 mM | 0.247 ml | 1.236 ml | 2.472 ml |
| 5 mM | 0.049 ml | 0.247 ml | 0.494 ml |
Last Update：2024-01-02 23:10:35
Ozanimod - Nature
| Solubility | DMSO (Slightly), Methanol (Slightly) |
Last Update：2024-04-10 22:29:15
Ozanimod - Uses and synthesis methods
Introduction
Ozamod is a potential sphingosine phosphate 1 receptor agonist for the treatment of multiple sclerosis (MS) and ulcerative colitis jointly developed by the American Scripps Research Institute and the American Celgene Company. It can induce peripheral blood lymphocyte isolation and reduce the number of activated lymphocytes circulating into the gastrointestinal tract. According to the detailed results of the consolidation period of TOUCHSTONE clinical trials, the clinical remission compliance or consolidation rate of patients in Ozamod treatment group was significantly higher than that in placebo group at week 32.
Ozamod is an agonist that binds to S1P1 and S1P5 receptors. Rodent experiments have shown that Ozanimo is effective against autoimmune diseases.
Preparation
To a solution of N,N-dimethylformamide (110 ml) of the compound of formula V (27.5g, 0.1 mol), carbodiimide (23.0g, 0.12 mol) and 1-hydroxybenzotriazole (16.2g, 0.12 mol) were added to the solution of the compound of formula V (20.5g, 0.1 mol) under nitrogen protection. Reacting at room temperature for 2 hours, then heating the reaction mixture to 80°C for 12 hours. The reaction mixture was cooled to room temperature and diluted with ethyl acetate (250 ml). The organic layer was washed with NaHCO3, water and brine. The combined organic layer is dried by MgSO4 and concentrated to produce 46.0 grams of white foam solid, the compound of formula VII, which can be directly used in the next reaction without purification.
Prospects for Development
The industry is also very optimistic about Ozamod's business prospects. Dr. StephenHanauer, medical director of Northwest Medical Digestive Health Center, said: "The consolidation data of this trial, together with the previously reported induction data, suggest that the oral drug Ozamod is expected to help patients with moderate to severe ulcerative colitis.
in vitro studies
In S1P1R-HEK293T cells, Ozanimod induce continuous internalization and degradation of S1P1R.
In vivo studies
In vitro, Ozanimod showed high oral bioavailability and volume distribution volume. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) inhibited clinical symptoms. In a rat TNBS model with inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibited the incidence of clinical and histological disease. In the natural CD4 CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) will also significantly reduce the severity of the disease by measuring inflammation, gland loss, hyperplasia, neutrophil infiltration and mucosal thickness.
Last Update：2024-04-10 22:29:15
Supplier List
Featured ProductsSpot supply
Product Name: Ozanimod (RPC1063) Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Ozanimod Request for quotationCAS: 1306760-87-1
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: Ozanimod Request for quotationCAS: 1306760-87-1
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: Ozanimod Request for quotationCAS: 1306760-87-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Ozanimod Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: RPC-1063 Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Ozanimod Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Ozanimod Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Ozanimod (RPC1063) Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Ozanimod Request for quotationCAS: 1306760-87-1
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: Ozanimod Request for quotationCAS: 1306760-87-1
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: Ozanimod Request for quotationCAS: 1306760-87-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Ozanimod Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: RPC-1063 Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Ozanimod Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Ozanimod Visit Supplier Webpage Request for quotationCAS: 1306760-87-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History