PD0166285
PD0166285
CAS: 185039-89-8
Molecular Formula: C26H27Cl2N5O2
PD0166285 - Names and Identifiers
PD0166285 - Physico-chemical Properties
| Molecular Formula | C26H27Cl2N5O2 |
| Molar Mass | 512.43 |
| Density | 1.315±0.06 g/cm3(Predicted) |
| Boling Point | 665.3±65.0 °C(Predicted) |
| pKa | 9.65±0.25(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| In vitro study | PD0166285 can inhibit the activity of Wee1 at micromolar concentration, which eliminates the G2/M phase DNA damage checkpoint, causing the cell to enter early cell division (DNA damage repair has not been performed). On the seven cancer cell lines detected, 0.5 μm of PD0166285 significantly inhibited radiation-induced Cdc2 phosphorylation (pTyr-15 and pThr-14). PD0166285 enables cells to skip the G2/M phase DNA damage checkpoint to induce cells to enter early division. Apoptosis can be used to kill cancer cells. PD0166285 did not inhibit Cdc2/cyclin B, but inhibited Chk1 at higher concentrations (3433 nM). Treatment of cells with PD0166285 inhibited cyclin D transcription and correlated with microtubule stability. |
| In vivo study | Inhibition of Wee1 by PD0166285 sensitizes U251-FM of malignant gliomas to radiation in vivo. |
PD0166285 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.951 ml | 9.757 ml | 19.515 ml |
| 5 mM | 0.39 ml | 1.951 ml | 3.903 ml |
| 10 mM | 0.195 ml | 0.976 ml | 1.951 ml |
| 5 mM | 0.039 ml | 0.195 ml | 0.39 ml |
Last Update：2024-01-02 23:10:35
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