Molecular Formula | C27H41F2N5O |
Molar Mass | 489.64 |
Appearance | powder |
Color | white to beige |
Storage Condition | room temp |
Use | Nirogacestat (PF-3084014) is an effective, orally active, reversible, non-competitive selective γ-secretase inhibitor with an IC50 of 6.2 nM. Nirogacestat inhibit Notch signaling pathway while minimizing gastrointestinal toxicity. It can be used to study Notch receptor-dependent tumors. |
Target | γ secretase |
HS Code | 29332900 |
Reference Show more | 1. Wei P, et al. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther. 2010 Jun;9(6):1618-28. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.042 ml | 10.212 ml | 20.423 ml |
5 mM | 0.408 ml | 2.042 ml | 4.085 ml |
10 mM | 0.204 ml | 1.021 ml | 2.042 ml |
5 mM | 0.041 ml | 0.204 ml | 0.408 ml |
biological activity | Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor, the IC50 in the cell-free assay was 6.2 nM. Nirogacestat (PF-03084014, PF-3084014) induced apoptosis. Phase 2. |
Target | TargetValue gamma-secretase (cell-free assay) 6.2 nM |
Target | Value |
γ-secretase (cell-free assay) | 6.2 nM |