PHTALIMIDE
Phthalimide
CAS: 85-41-6
Molecular Formula: C8H5NO2
PHTALIMIDE - Names and Identifiers
| Name | Phthalimide |
| Synonyms | PHTALIMIDE Phthalimide o-Phthalimide O-PHTHALIC IMIDE 1,3-ISOINDOLEDIONE 1,2-PHTHALIC IMIDE 2,5-Isoindoledione Isoindole-1,3-dione ISOINDOLE-1,3-DIONE PHTHALIMIDE,REAGENT Isoindoline-1,3-dione LABOTEST-BB LTBB000782 2H-Isoindole-1,3-dione Potassium phthalylimide 1,2-BENZENEDICARBOXIMIDE 1H-ISOINDOLE-1,3(2H)-DIONE 1,3-DIHYDROISOINDOLE-1,3-DIONE 1,3-dihydro-1,3-dioxoisoindole Benzene-1,2-dicarboxylic acid imide |
| CAS | 85-41-6 |
| EINECS | 201-603-3 |
| InChI | InChI=1/C8H5NO2/c10-7-5-3-1-2-4-6(5)8(11)9-7/h1-4H,(H,9,10,11) |
| InChIKey | XKJCHHZQLQNZHY-UHFFFAOYSA-N |
PHTALIMIDE - Physico-chemical Properties
| Molecular Formula | C8H5NO2 |
| Molar Mass | 147.13 |
| Density | 1.21 |
| Melting Point | 232-235°C(lit.) |
| Boling Point | 366 °C |
| Flash Point | 165 °C |
| Solubility | water: slightly soluble(lit.) |
| Vapor Presure | 0.001Pa at 25℃ |
| Appearance | Crystalline Flakes |
| Color | White to slightly yellow |
| Merck | 14,7373 |
| BRN | 118522 |
| pKa | 8.3(at 25℃) |
| PH | 3.8 (0.6g/l, H2O) |
| Storage Condition | Store below +30°C. |
| Refractive Index | 1.4700 (estimate) |
| Physical and Chemical Properties |
|
| Use | For the production of pesticides, dyes, spices, pharmaceuticals, rubber additives CTP, but also for the production of efficient ion exchange resins, surfactants |
PHTALIMIDE - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | TI3920000 |
| TSCA | Yes |
| HS Code | 29251995 |
| Toxicity | LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg |
PHTALIMIDE - Upstream Downstream Industry
| Raw Materials | Ammonium hydroxide Phthalic anhydride |
| Downstream Products | N-(Cyclohexylthio)phtalimide |
PHTALIMIDE - Nature
Open Data Verified Data
The Pure product is a white and brittle crystalline powder, and the industrial product is a pale yellow amorphous block. Melting point 238 °c. Slightly soluble in water, soluble in alkali solution, acetic acid and pyridine, slightly soluble in heated chloroform, benzene and ether.
Last Update：2025-06-10 22:55:16
PHTALIMIDE - Preparation Method
Open Data Verified Data
There are two methods: ammonium bicarbonate method and urea method
- ammonium carbonate phthalic anhydride and ammonium bicarbonate were crushed evenly and then put into the kettle for reaction, heated to 200 ℃ for about 4H, then heated to 280~300 ℃ at a faster rate, and the melt was discharged, the product is obtained by cooling and solidifying.
- urea method phthalic anhydride and urea are mixed and reacted in a pre-heated reaction kettle for 15-20min. After completion of the reaction, water is added to precipitate crystals, and the product is obtained after drying.
Last Update：2022-01-01 10:52:44
PHTALIMIDE - Application
Open Data Verified Data
This product can be used for the production of pesticides, dyes, spices and medicines, but also for the production of anthranilic acid and isatoic anhydride.
Last Update：2025-08-19 16:24:40
PHTALIMIDE - Application
Open Data Verified Data
- toxic nitrogen oxide gas is emitted by heat. It can be poisoned if taken by mistake. Slightly irritating to the skin.
- glass bottles, plastic bottles outside the wooden box lining bedding or fiber barrels, metal barrels lined with plastic bags. Store in a cool and ventilated warehouse, away from fire and heat source. Isolation storage and transportation of food raw materials. The container should be handled with light weight to prevent damage to the container.
Last Update：2025-08-19 16:24:40
PHTALIMIDE - Reference Information
| sublimation point | 366°C |
| LogP | 1.15 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | phthalimide is an intermediate of fungicide, insecticide, thiophos and herbicide, fumarate. for the production of pesticides, dyes, spices, pharmaceuticals, rubber additives CTP, can also be used to produce efficient ion exchange resin, surfactants, etc. used in organic synthesis This product is an intermediate of many fine chemicals, such as secondary dyes, pesticides, pharmaceuticals, rubber additives, etc., such as for the production of phthalein, phthalonitrile, Indigo, bactericidal fungicide, insecticide, and so on. for the production of pesticides, dyes, spices and pharmaceuticals, rubber additives CTP; For the production of efficient ion exchange resin, surfactants, heavy metal extractants, etc. |
| production method | There are many methods for preparing phthalimide from phthalic anhydride, the practical application of industrial production is the ammonium carbonate method and urea method. 1. Ammonium carbonate method phthalic anhydride and ammonium bicarbonate are mixed at a molar ratio of 1:1.2, crushed by a pulverizer, and then put into a reaction kettle, heated for about 4H to 200 ° C., and then heated to 280-300 ° C. At a slightly faster speed. The melt was discharged to crystallization, cooled, solidified and pulverized to obtain a finished product with a yield of more than 95%. Phthalimide content of 95% per ton need to consume phthalic anhydride 1030kg, 95% ammonium bicarbonate 660kg. 2. Urea method There are two preparation methods in industrial production: ammonium bicarbonate method and urea method. (1) Ammonium carbonate method phthalic anhydride and ammonium bicarbonate (liquid ammonia or ammonia water) are uniformly mixed at a molar ratio of 1: 1.2, then heated at 300 ° C. In a reaction tank, cooled and pulverized to obtain a finished product. (2) urea method phthalic anhydride and urea mixed evenly, heated and stirred, to be all melted, keep 160 ℃, about 10min, the volume of reactants suddenly increased, stop heating, continue to stir, until the reactants solidify, heat them over a large fire and stop heating after a few minutes, Constant stirring, after a certain period of time, water filtration, first with 3% sodium bicarbonate wash, then wash, dry to get the finished product. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | intraperitoneal-rat LD50: 500 mg/kg; Oral-mouse LD50: 5000 mg/kg |
| flammability hazard characteristics | toxic nitrogen oxide gas emitted by heat |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | carbon dioxide, sand, foam, dry powder |
| spontaneous combustion temperature | >500°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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Raw Materials for PHTALIMIDE
Downstream Products for PHTALIMIDE