Name | Polysaccharide |
Synonyms | Polysaccharide Glossy ganoderMa Ganodermic polysaccharide ganoderMa luciduM polysacchride Ganoderma lucidum Polysaccharides |
Solubility | Soluble in water |
Appearance | Brown powder |
Storage Condition | 2-8℃ |
Reference Show more | 1. [IF=5.717] Qing Huang et al."GPP (Composition of Ganoderma lucidum Poly-saccharides and Polyporus umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice."Nutrients. 2019 Jul;11(7):1480 2. [IF=5.154] Liyuan Li et al."GPP (composition of Ganoderma lucidum polysaccharides and Polyporus umbellatus polysaccharides) protects against DSS-induced murine colitis by enhancing immune function and regulating intestinal flora."Food Science and Human Wellness. 2022 |
trait | the appearance of Ganoderma lucidum polysaccharide is light brown to brown powder, soluble in hot water. |
uses | Ganoderma lucidum polysaccharides have hypoglycemic, hypolipidemic, antithrombotic, antioxidant, scavenging free radicals, anti-aging, anti-radiation, anti-tumor, promote blood circulation, regulate immunity, regulate nucleic acid, protein metabolism, promote DNA synthesis, promote the proliferation of human umbilical cord blood LAK cells. |
Application | Ganoderma lucidum polysaccharide has unique physiological activity and clinical effect, and is safe and non-toxic, can be widely used in medicine, food and cosmetic industries. It can improve the immunity of the body, in the case of cancer patients with radiotherapy and chemotherapy, the immune system is damaged, and radiotherapy, chemotherapy can achieve the purpose of curing the disease. In addition, Ganoderma lucidum polysaccharide can also inhibit the release of allergic reaction medium, thereby blocking the occurrence of non-specific reaction, and thus can inhibit the recurrence and metastasis of cancer cells after surgery. As a functional factor, it can be made into health food, and can also be used as a food additive to add to beverages, cakes, oral liquids, which have greatly enriched the food market. Since Ganoderma lucidum polysaccharide has the effect of anti-free radical, it can be used in cosmetics to delay aging. |
The most effective component in Ganoderma lucidum | Ganoderma lucidum polysaccharide was originally composed of Ganoderma lucidum (Ganoderma lucidum) there are more than 200 kinds of Ganoderma lucidum polysaccharides isolated from two kinds of hypoglycemic active polysaccharides Ganoderan A and B in the fruiting body. Most of them are β-glucans and a few are α-glucans. The polysaccharide chain is composed of three-stranded monosaccharide chains, which is a helical stereostructure similar to DNA and RNA, the helical layers are mostly fixed by hydrogen bonds with molecular weights ranging from hundreds to hundreds of thousands. High molecular polysaccharide body function to enhance the body's immune system, with the main active ingredient, is the main ingredient of Ganoderma lucidum in the treatment of various diseases. In addition to a small part of small molecule polysaccharide, mostly insoluble in high concentration of alcohol, and soluble in hot water. Ganoderma lucidum polysaccharide is one of the most effective components of Ganoderma lucidum, so it has attracted much attention of medical workers. It is reported that Ganoderma lucidum polysaccharides have the characteristics of stimulating host non-specific resistance, immune specific response and inhibiting the physiological activity of transplanted tumors. When the molecular weight of polysaccharide is greater than 10000, it shows strong tumor inhibitory activity, and the activity is also related to the degree of branching of polysaccharide chain and the number of hydroxyl groups in branched chain. Another report, Ganoderma lucidum polysaccharide can also improve the body's immunity, improve the body's ability to resist hypoxia, eliminate free radicals, anti-radiation, improve the liver, bone marrow, blood DNA, RNA and protein capacity, thereby prolonging life. |
Ganoderma lucidum | lionyd G. Gan-oderma lucidum (Leyss. exfr.) karst. The whole plant. Produced in Zhejiang, Jiangxi, Hunan, Guangxi, Fujian, Guangdong, Guizhou and other places.|
polysaccharide compound | a polysaccharide compound is a macromolecular compound in which one or more monosaccharides are linked by a glycoside chain. Their structures are complex, most of them are amorphous compounds, and the relative molecular mass is large. Polysaccharides widely exist in higher plants, bacteria, fungi and animals in nature, especially in Chinese herbal medicine. The main monosaccharides of polysaccharides are glucose, mannose, galactose, xylose and arabinose. The extensive research on polysaccharides began in the 60s of the 20th century. At present, the polysaccharides that have been studied and applied are Codonopsis pilosula polysaccharide, Cordyceps mycelium polysaccharide, tremella polysaccharide, Ganoderma lucidum polysaccharide, lentinan polysaccharide, Polyporus polysaccharide, Lycium barbarum polysaccharide and spirulina polysaccharide. These polysaccharides are generally non-specific immune enhancer, to improve the body's immune resistance. For example, it can be used for patients with hepatitis and AIDS who have no specific effect on the pathogen Virus to improve their own resistance. In addition, it can also be used for lowering blood sugar, lowering blood fat, lowering blood cholesterol, anti coagulation and reducing lipid peroxidation in the body. Polysaccharide nutritional health food also has certain anti-tumor effect, such as polysaccharide composed of polydextrose, lentinan and Ganoderma lucidum polysaccharide have certain anti-cancer activity. Because these polysaccharides are extracted from natural Chinese herbal medicine, it is relatively safe. |
Anti-aging effect | 1. Polysaccharides and peptides contained in Ganoderma lucidum have obvious anti-aging effect. 2. The decrease of the antioxidant or antioxidant enzyme substances (such as superoxide dismutase, SOD) produced by the organism to damage the endogenous defense free radicals is one of the causes of human aging. Ganoderma lucidum polysaccharide has a significant SOD activity, can significantly remove the free radicals produced by the body, so as to prevent the damage of free radicals to the body, prevent the peroxidation of the body, protect the cells, delay cell aging. 3, Ganoderma lucidum polysaccharide can significantly promote the nuclear DNA synthesis ability, and can increase the cell division generation, so as to delay the aging of the body. |
immune enhancing effect | Ganoderma lucidum can obviously enhance the immune function of normal mice. It has a significant immune enhancement effect on mice with low immune function caused by aging, immunosuppressive drugs and anticancer drugs. (1) improve non-specific immune function Ganoderma lucidum polysaccharides can improve the body's immune function, can enhance the phagocytosis of macrophages; And can improve the function of granulocytes. Significantly promote lymphocyte proliferation. (2) enhance the activity of NK can eliminate the inhibitory effect of chemical drugs, such as cyclophosphamide on lymphocytes; Significantly improve the activity of natural killer cells (NK), reduces the inhibitory effect of chemicals on NK cells. (3) enhancing production of interleukin Ganoderma lucidum polysaccharides can enhance the ability of activated macrophages to produce interleukin-1 (IL-1); and can promote the spleen cells to produce Interleukin -2(IL-2). (4) promoting the production of tumor necrosis factor (TNF) Ganoderma lucidum polysaccharides can promote macrophages to produce tumor necrosis factor, cause tumor hemorrhage and necrosis, and directly kill tumor cells. Ganoderma lucidum extract can induce the transformation of body immunity to Th1 type and improve the basic immune function of tumor-bearing body. The combination with CpG-ODN or HSP70-PCs and other immunotherapeutic agents can enhance the effect of immunotherapy. (5) enhancing the activity of DNA polymerase α of immune cells Ganoderma lucidum polysaccharides can promote the activity of DNA polymerase α of spleen cells, enhance the DNA synthesis of immune cells and cell proliferation, accelerates the immune response. (6) antagonizing the immunosuppressive effect of chemotherapeutic drugs Ganoderma lucidum polysaccharides can completely antagonize the immunosuppression of cyclosporine A, mitomycin C, cytarabine, fluorouracil and hydrocortisone in mice, and has a significant recovery effect. (7) regulation of humoral immunity The effect of Ganoderma lucidum on humoral immunity is biphasic. It not only improves humoral immunity, but also inhibits humoral immunity and anti-allergic reaction. This may be related to the complex components contained in Ganoderma lucidum. Ganoderma lucidum polysaccharides can enhance humoral immunity, enhance delayed hypersensitivity and increase IgG content. Ganoderma lucidum also has the effect of inhibiting humoral immunity, and has obvious inhibitory effect on lymphocyte DNA synthesis and concanavalin A(ConA)-induced T cell and B cell transformation, it has obvious inhibitory effect on the proliferation of mouse spleen lymphocytes and can inhibit mouse spleen antibody secreting cells in vivo. |